Kihm U
Dev Biol Stand. 1976;35:149-53.
The report compares the compatibility, efficacity and serology response of two bivalent anti-foot-and-mouth disease vaccines (OC). One is oil-adjuvanted and the other based on diethyl-amino-ethyl-dextran (DEAE-Dextran). After vaccination no general clinical or local reactions are normally observed. Tissular reactions at the inoculation site are more severe with the oil-adjuvanted vaccine than with the DEAE-Dextran vaccine. Meat inspection, about three months after injection of the vaccine, showed the lesions to be in regression and negligible. The control of activity has been performed by the virulence test. For the oil-adjuvanted vaccine, protection against O1-Lausanne, 5, 21 and 90 days after vaccination is 90%, 80-100% and 55% respectively. For the DEAE-Dextran vaccine, these levels of protection are 80% after 5 days and 20-70% after 21 days. The percentage of swine protected against C-Noville 35 days after vaccination is 100% for the oil-adjuvanted vaccine and 70% for the DEAE-Dextran vaccine. The evolution of the amount of serum antibodies was followed for three months by the method of seroneutralization on cell cultures.
该报告比较了两种二价口蹄疫疫苗（OC）的兼容性、效力和血清学反应。一种是油佐剂疫苗，另一种是基于二乙氨基乙基葡聚糖（DEAE - 葡聚糖）的疫苗。接种疫苗后，通常不会观察到全身性临床反应或局部反应。油佐剂疫苗接种部位的组织反应比DEAE - 葡聚糖疫苗更严重。在注射疫苗约三个月后进行的肉类检查显示，病变正在消退且可忽略不计。活性控制通过毒力试验进行。对于油佐剂疫苗，接种疫苗后5天、21天和90天对O1 - 洛桑毒株的保护率分别为90%、80 - 100%和55%。对于DEAE - 葡聚糖疫苗，接种疫苗后5天的保护率为80%，21天后为20 - 70%。接种疫苗35天后，油佐剂疫苗对C - 诺维尔毒株的猪保护率为100%，DEAE - 葡聚糖疫苗为70%。通过细胞培养血清中和法对血清抗体量的变化进行了三个月的跟踪。
