Deakin Inga H, Law Amanda J, Oliver Peter L, Schwab Markus H, Nave Klaus Armin, Harrison Paul J, Bannerman David M
Department of Psychiatry, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
Neuroreport. 2009 Nov 25;20(17):1523-8. doi: 10.1097/WNR.0b013e328330f6e7.
Neuregulin 1 (NRG1) is a pleiotropic growth factor involved in diverse aspects of brain development and function. In schizophrenia, expression of the NRG1 type I isoform is selectively increased. However, virtually nothing is known about the roles of this isoform in brain. We have studied transgenic mice overexpressing type I NRG1(NRG1type 1-tg) using a series of behavioural tests. NRG1(type 1-tg) mice have a tremor, are impaired on the accelerating rotarod, and have reduced prepulse inhibition in the context of an increased baseline startle response. There is no overall anxiety or activity phenotype, although female NRG(1type 1-tg) mice show mild increases in anxiety on some measures. The pattern of results shows both similarities and differences to those reported in hypomorphic NRG1 mice, and may be relevant for interpreting the increased NRG1 type I expression observed in schizophrenia.
神经调节蛋白1（NRG1）是一种多效性生长因子，参与大脑发育和功能的多个方面。在精神分裂症中，I型NRG1亚型的表达选择性增加。然而，关于该亚型在大脑中的作用几乎一无所知。我们使用一系列行为测试研究了过表达I型NRG1的转基因小鼠（NRG1 I型转基因小鼠）。NRG1（I型转基因）小鼠有震颤，在加速旋转杆试验中表现受损，并且在基线惊吓反应增加的情况下前脉冲抑制降低。虽然雌性NRG（I型转基因）小鼠在某些指标上显示出焦虑略有增加，但没有整体焦虑或活动表型。结果模式与低表达NRG1小鼠报道的结果既有相似之处也有不同之处，可能与解释在精神分裂症中观察到的I型NRG1表达增加有关。
