Murialdo Roberto, Boy Davide, Musizzano Yuri, Tixi Lucia, Murelli Federica, Ballestrero Alberto
Deventer Hospital, Department of Surgery, Postbus 5001, 7400 GC Deventer, the Netherlands.
Cases J. 2009 Jul 10;2:7336. doi: 10.4076/1757-1627-2-7336.
Pure primary squamous cell carcinoma of the breast is uncommon and it's debated the correct management of this disease.
A 54-years-old woman presented with signs and symptoms of mastitis of left breast. A palpable well circumscribed and firm mass, measuring about 40 mm, was present in the left lower lateral quadrant. She underwent antibiotic therapy without benefit. She performed an ultrasound and mammographic scan of the left breast. Fine needle aspiration cytology revealed an infiltrative poorly differentiated squamous cell carcinoma. Total body CT scan and bone scan excluded distant metastasis. Subsequently wide local excision of the left breast with ipsilateral axillary lymph nodes dissection was performed. The pathological examination revealed an infiltrative poorly differentiated squamous cell carcinoma of the breast. Adjuvant chemotherapy cisplatin and 5-fluorouracil based was administered. Patient refused locoregional radiotherapy. Twenty-eight months after surgery the patient was disease free.
Pure primary squamous cell carcinoma of the breast is a rare and aggressive disease often treatment-refractory. An optimal systemic treatment is needed to improve patient's outcome.
乳腺原发性单纯鳞状细胞癌并不常见，对于这种疾病的正确治疗方法存在争议。
一名54岁女性出现左乳乳腺炎的症状和体征。左乳外下象限可触及一个边界清晰、质地坚硬的肿块，大小约40毫米。她接受了抗生素治疗但无效。她进行了左乳超声和乳腺钼靶扫描。细针穿刺细胞学检查显示为浸润性低分化鳞状细胞癌。全身CT扫描和骨扫描排除了远处转移。随后进行了左乳广泛局部切除并清扫同侧腋窝淋巴结。病理检查显示为乳腺浸润性低分化鳞状细胞癌。给予了以顺铂和5-氟尿嘧啶为基础的辅助化疗。患者拒绝局部区域放疗。术后28个月患者无疾病复发。
乳腺原发性单纯鳞状细胞癌是一种罕见且侵袭性强的疾病，通常对治疗耐药。需要优化全身治疗以改善患者的预后。
