Department of Genetics, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel.
J Cell Mol Med. 2009 Nov-Dec;13(11-12):4304-18. doi: 10.1111/j.1582-4934.2009.00952.x. Epub 2009 Oct 23.
Carbon dioxide (CO(2)) is an important gaseous molecule that maintains biosphere homeostasis and is an important cellular signalling molecule in all organisms. The transport of CO(2) through membranes has fundamental roles in most basic aspects of life in both plants and animals. There is a growing interest in understanding how CO(2) is transported into cells, how it is sensed by neurons and other cell types and in understanding the physiological and molecular consequences of elevated CO(2) levels (hypercapnia) at the cell and organism levels. Human pulmonary diseases and model organisms such as fungi, C. elegans, Drosophila and mice have been proven to be important in understanding of the mechanisms of CO(2) sensing and response.
二氧化碳（CO(2)）是一种重要的气态分子，它维持着生物圈的平衡，也是所有生物体中重要的细胞信号分子。CO(2)通过细胞膜的运输在动植物的生命的大多数基本方面都起着基础性的作用。人们越来越感兴趣的是了解 CO(2)是如何进入细胞的，它如何被神经元和其他细胞类型感知，以及了解细胞和生物体水平升高的 CO(2)水平（高碳酸血症）的生理和分子后果。已经证明，人类肺部疾病和模式生物（如真菌、秀丽隐杆线虫、果蝇和老鼠）在理解 CO(2)感应和反应的机制方面非常重要。
