伴有甲状腺刺激阻断抗体（TSBAb）的寂静性甲状腺炎。
Silent thyroiditis with thyroid-stimulation-blocking antibodies (TSBAb).
作者信息
Nakamura S, Sugimoto M, Kosaka J, Watanabe H, Shima H, Kawahira S
机构信息
Department of Internal Medicine, Gifu Red Cross Hospital, Japan.
出版信息
Jpn J Med. 1990 Nov-Dec;29(6):623-7. doi: 10.2169/internalmedicine1962.29.623.
A 24-year-old man showed thyrotoxic symptoms with hypokalemic periodic paralysis. Serum thyroid hormone levels were high and thyrotropin (TSH) was undetectable. 123I-thyroidal uptake was suppressed. TSH-binding inhibitor immunoglobulin (TBII) was positive. After a month without any treatment, he became hypothyroid. Thyroid hormone level was decreased and TSH was increased to above the normal range. 123I-thyroidal uptake was increased. TBII activity was still positive. From the clinical findings, a diagnosis of silent thyroiditis was made. Sera obtained in the hypothyroid state revealed the presence of thyroid-stimulation-blocking antibodies (TSBAb), but there were no thyroid-stimulating antibodies (TSAb). These results suggest that the hypothyroidism in this patient was due to the presence of TSBAb with TBII activity.
一名24岁男性出现甲状腺毒症症状并伴有低钾性周期性麻痹。血清甲状腺激素水平升高，促甲状腺激素（TSH）检测不到。123I甲状腺摄取被抑制。促甲状腺激素结合抑制性免疫球蛋白（TBII）呈阳性。未经任何治疗一个月后，他出现了甲状腺功能减退。甲状腺激素水平降低，TSH升高至正常范围以上。123I甲状腺摄取增加。TBII活性仍为阳性。根据临床 findings，诊断为寂静性甲状腺炎。在甲状腺功能减退状态下获得的血清显示存在甲状腺刺激阻断抗体（TSBAb），但没有甲状腺刺激抗体（TSAb）。这些结果表明该患者的甲状腺功能减退是由于具有TBII活性的TSBAb的存在。
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