Arthritis Res Ther. 2009;11(5):127. doi: 10.1186/ar2788. Epub 2009 Oct 1.
Changes in metacarpal cortical bone mineral density (BMD) using digital x-ray radiogrammetry were studied in patients with early rheumatoid arthritis. After 1, 2, and 5 years, large BMD losses were found: -1.7%, -2.8%, and -5.6%, respectively. Elevated erythrocyte sedimentation rate and anti-cyclic citrullinated peptide levels were independent predictors of bone loss, indicating that the largest amount of bone loss was found in patients with severe inflammation and high production of auto-antibodies, who are known to be at the highest risk of developing radiological bone damage. Studies are needed about the spatial and time relationship between erosions and juxta-articular and metacarpal bone loss.
研究了早期类风湿关节炎患者掌骨皮质骨骨密度（BMD）的变化，使用数字 X 射线射线照相术。1、2 和 5 年后，发现 BMD 大量流失：分别为-1.7%、-2.8%和-5.6%。红细胞沉降率和抗环瓜氨酸肽水平升高是骨丢失的独立预测因子，表明在炎症严重和自身抗体产量高的患者中发现了最大量的骨丢失，这些患者已知处于发生放射学骨损伤的最高风险中。需要研究侵蚀与关节旁和掌骨骨丢失之间的空间和时间关系。
