早期造血过程中的发育轨迹。
Developmental trajectories in early hematopoiesis.
作者信息
Murre Cornelis
机构信息
Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093, USA.
出版信息
Genes Dev. 2009 Oct 15;23(20):2366-70. doi: 10.1101/gad.1861709.
Abstract
The paths that hematopoietic stem cells take to develop from multipotent, self-renewing cells into committed lymphocytes has been a topic of debate for some time. During early hematopoiesis, multiple branchpoints have been described in which progeny cells segregate into cell lineages with distinct developmental potentials. In this issue of Genes & Development, Inlay and colleagues (pp. 2376-2381) identify novel intermediate stages through which hematopoietic progenitor cells travel.
摘要
造血干细胞从多能、自我更新细胞发育为定向淋巴细胞所经历的途径，一段时间以来一直是争论的话题。在早期造血过程中，已描述了多个分支点，子代细胞在这些分支点处分离为具有不同发育潜能的细胞谱系。在本期《基因与发育》中，英莱及其同事（第2376 - 2381页）确定了造血祖细胞所经历的新的中间阶段。
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本文引用的文献
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E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitors.E2A蛋白维持造血干细胞池，并促进骨髓淋巴细胞和骨髓红系祖细胞的成熟。
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