Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infectious Diseases and Immunology Amsterdam, Academic Medical Center, University of Amsterdam, the Netherlands.
Retrovirology. 2009 Oct 16;6:93. doi: 10.1186/1742-4690-6-93.
We discuss a recent Nature Medicine publication by Philip Johnson and co-workers (Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys. Nat. Med. 2009, 15: 901-906) in which an effective HIV-1 vaccine was designed that is based on gene therapy. The introduced gene produces an antibody-like immunoadhesin in the blood that neutralizes the virus.
我们讨论了最近发表在《自然医学》杂志上的一篇文章，这篇文章由 Philip Johnson 及其同事撰写（Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys. Nat. Med. 2009, 15: 901-906），文中设计了一种基于基因治疗的有效 HIV-1 疫苗。引入的基因在血液中产生一种类似抗体的免疫黏附素，可中和病毒。
