干扰素对淋巴细胞有丝分裂的抑制作用。
Interferon inhibition of lymphocyte mitogenesis.
作者信息
Weinstein Y, Brodeur B R, Melmon K L, Merigan T C
出版信息
Immunology. 1977 Sep;33(3):313-9.
Abstract
Interferon inhibits the early phase of mitogenic action of Concanavalin A on lymphocytes as measured by incorporation of labelled precursors in RNA, DNA or protein. There was no evidence for a role of cyclic AMP in the process of inhibition. Dialysis of interferon against high salt and urea did not separate cell inhibitory activity from antiviral activity. Thus, these results are compatible with the possibility that the antiviral and cell inhibitory activities are in the same molecule. However, further purification of the interferon will be required to verify this assumption.
摘要
通过标记前体掺入RNA、DNA或蛋白质来衡量，干扰素可抑制伴刀豆球蛋白A对淋巴细胞的促有丝分裂作用的早期阶段。没有证据表明环磷酸腺苷在抑制过程中发挥作用。用高盐和尿素对干扰素进行透析，并未将细胞抑制活性与抗病毒活性分离。因此，这些结果与抗病毒活性和细胞抑制活性存在于同一分子中的可能性相符。然而，需要对干扰素进行进一步纯化以验证这一假设。
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Interferon inhibition of lymphocyte mitogenesis.干扰素对淋巴细胞有丝分裂的抑制作用。
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