干扰素对新生小鼠和成年小鼠免疫反应的调节
Modulation of immune responses in newborn and adult mice by interferon.
作者信息
Strannegård O, Larsson I, Lundgren E, Miörner H, Persson H
出版信息
Infect Immun. 1978 May;20(2):334-9. doi: 10.1128/iai.20.2.334-339.1978.
Abstract
Interferon was found to have both suppressive and enhancing effects on the antibody response in newborn and adult mice. Evidence was obtained that these effects are primarily evoked during the initial steps controlling cell proliferation. Stimulation of thymus and spleen cells with a T-cell mitogen was enhanced by low doses and suppressed by high doses of interferon. Treatment of parental spleen cells with interferon before injecting them into immunized F1 hybrid mice resulted in an enhanced allogeneic effect. These results are compatible with the hypothesis that interferon affects T cells and has an immunoregulatory role, either by inhibiting the action of suppressor cells or by promoting immunological maturation.
摘要
干扰素被发现对新生小鼠和成年小鼠的抗体反应具有抑制和增强作用。有证据表明，这些作用主要在控制细胞增殖的初始阶段诱发。低剂量干扰素可增强T细胞有丝分裂原对胸腺和脾细胞的刺激作用，高剂量则抑制该作用。在用亲本脾细胞注射免疫的F1杂种小鼠之前，先用干扰素处理亲本脾细胞，可增强同种异体效应。这些结果与以下假设相符：干扰素通过抑制抑制细胞的作用或促进免疫成熟来影响T细胞并具有免疫调节作用。
相似文献
1
Modulation of immune responses in newborn and adult mice by interferon.干扰素对新生小鼠和成年小鼠免疫反应的调节
Infect Immun. 1978 May;20(2):334-9. doi: 10.1128/iai.20.2.334-339.1978.
2
Mechanism of the suppressive effect of interferon on antibody synthesis in vivo.干扰素对体内抗体合成抑制作用的机制。
J Immunol. 1975 Apr;114(4):1323-8.
3
Enhancement of the allogeneic effect by irradiation of transferred cells.
Int Arch Allergy Appl Immunol. 1977;53(2):110-5. doi: 10.1159/000231740.
4
Interferon immunoregulation of antibody response in normal and autoimmune mice is mediated by suppressor T cell subsets.正常小鼠和自身免疫小鼠中抗体反应的干扰素免疫调节由抑制性T细胞亚群介导。
Int Arch Allergy Appl Immunol. 1981;64(3):353-8. doi: 10.1159/000232714.
5
Effects of interferon on antibody synthesis in vitro.干扰素对体外抗体合成的影响。
J Immunol. 1974 Aug;113(2):438-44.
6
7
Effect of interferon on antibody formation.干扰素对抗体形成的影响。
Tex Rep Biol Med. 1977;35:357-69.
8
9
Measurement of interferon modulation of the in vitro antibody response.
Methods Enzymol. 1981;79(Pt B):506-9. doi: 10.1016/s0076-6879(81)79065-7.
10
[Possibility of regulating the immunological activity of the lymphoid system by thymus gland factors. 2. Stimulation of antibody synthesis in various lymphoid formations of newborn puppies by a fraction of a calf thymus extract].[胸腺因子调节淋巴系统免疫活性的可能性。2. 小牛胸腺提取物的一个组分对新生幼犬各种淋巴组织中抗体合成的刺激作用]
Zh Ushn Nos Gorl Bolezn. 1973 Nov-Dec;33(6):3-6.
引用本文的文献
1
Comparison of retroviral p15E-related factors and interferon alpha in head and neck cancer.头颈部癌症中逆转录病毒p15E相关因子与α干扰素的比较。
Cancer Immunol Immunother. 1994 Mar;38(3):178-84. doi: 10.1007/BF01525639.
2
Mouse fibroblast interferon modifies Salmonella typhimurium infection in infant mice.小鼠成纤维细胞干扰素可改变幼鼠体内鼠伤寒沙门氏菌的感染情况。
Infect Immun. 1984 Jul;45(1):62-6. doi: 10.1128/iai.45.1.62-66.1984.
3
Effect of human leukocyte interferon on invasiveness of Salmonella species in HEp-2 cell cultures.人白细胞干扰素对HEp-2细胞培养物中沙门氏菌属侵袭性的影响。
Infect Immun. 1983 Dec;42(3):1198-202. doi: 10.1128/iai.42.3.1198-1202.1983.
4
Isoprinosine delays the early appearance of autoimmunity in NZB/NZW F1 mice treated with interferon.异丙肌苷可延缓经干扰素治疗的NZB/NZW F1小鼠自身免疫的早期出现。
Clin Exp Immunol. 1981 Jan;43(1):36-45.
5
Protective effect of low-dose interferon against neonatal murine cytomegalovirus infection.低剂量干扰素对新生小鼠巨细胞病毒感染的保护作用。
Infect Immun. 1981 Apr;32(1):332-42. doi: 10.1128/iai.32.1.332-342.1981.
6
Alterations of a mouse mammary tumor virus glycoprotein with interferon treatment.干扰素处理对小鼠乳腺肿瘤病毒糖蛋白的影响。
J Virol. 1980 Apr;34(1):225-33. doi: 10.1128/JVI.34.1.225-233.1980.
7
Increase of predominantly k-type light chains in the CSF of a case of subacute sclerosing panencephalitis treated with interferon.用干扰素治疗的亚急性硬化性全脑炎病例脑脊液中以k型轻链为主的增加。
Ital J Neurol Sci. 1985 Jun;6(2):215-9. doi: 10.1007/BF02229195.
本文引用的文献
1
Further improvements in the plaque technique for detecting single antibody-forming cells.用于检测单个抗体形成细胞的蚀斑技术的进一步改进。
Immunology. 1968 Apr;14(4):599-600.
2
A method for the large scale production of potent interferon preparations.一种大规模生产高效干扰素制剂的方法。
Proc Soc Exp Biol Med. 1974 Jul;146(3):809-15. doi: 10.3181/00379727-146-38196.
3
Production of high-titered interferon in cultures of human diploid cells.在人二倍体细胞培养物中产生高滴度干扰素。
Antimicrob Agents Chemother. 1972 Dec;2(6):476-84. doi: 10.1128/AAC.2.6.476.
4
Effects of interferon on antibody synthesis in vitro.干扰素对体外抗体合成的影响。
J Immunol. 1974 Aug;113(2):438-44.
5
Interferon preparations as modifiers of immune responses.作为免疫反应调节剂的干扰素制剂。
Proc Soc Exp Biol Med. 1972 Dec;141(3):769-73. doi: 10.3181/00379727-141-36868.
6
Enhancement by interferon of the expression of surface antigens on murine leukemia L 1210 cells.干扰素对小鼠白血病L 1210细胞表面抗原表达的增强作用。
Proc Natl Acad Sci U S A. 1973 Oct;70(10):2785-8. doi: 10.1073/pnas.70.10.2785.
7
Binding of interferon to gangliosides.干扰素与神经节苷脂的结合。
Nature. 1974 Dec 6;252(5483):478-80. doi: 10.1038/252478a0.
8
Differentiation of T cells induced by preparations from thymus and by nonthymic agents.胸腺制剂及非胸腺因子诱导的T细胞分化
J Exp Med. 1973 Oct 1;138(4):1027-32. doi: 10.1084/jem.138.4.1027.
9
Enhancement of phagocytosis by interferon-containing preparations.含干扰素制剂对吞噬作用的增强作用。
Infect Immun. 1971 Nov;4(5):581-8. doi: 10.1128/iai.4.5.581-588.1971.
10
Interferon and cyclic-3'5'-adenosine monophosphate: potentiation of antiviral activity.
Biochem Biophys Res Commun. 1969 Aug 22;36(5):735-40. doi: 10.1016/0006-291x(69)90671-8.
Zotero 插件