胰岛素瘤
Insulinoma.
作者信息
Mathur Aarti, Gorden Philip, Libutti Steven K
机构信息
Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Surg Clin North Am. 2009 Oct;89(5):1105-21. doi: 10.1016/j.suc.2009.06.009.
Abstract
Insulinoma is a rare neuroendocrine tumor with an incidence of 4 per 1 million persons per year, which may occur as a unifocal sporadic event in patients without an inherited syndrome or as a part of multiple endocrine neoplasia type 1. Key neuroglycopenic and hypoglycemic symptoms in conjunction with biochemical proof establish the diagnosis. Once the diagnosis is established, the insulinoma is preoperatively localized within the pancreas with the goal of surgical excision for cure. This review discusses the historical background, diagnosis, and management of sporadic insulinoma.
摘要
胰岛素瘤是一种罕见的神经内分泌肿瘤，年发病率为每100万人中有4例，可作为散发性单病灶事件发生在无遗传综合征的患者中，或作为1型多发性内分泌肿瘤的一部分。关键的神经低血糖症状和低血糖症状与生化证据相结合可确诊。一旦确诊，胰岛素瘤在术前需在胰腺内定位，目标是通过手术切除以治愈。本文综述讨论散发性胰岛素瘤的历史背景、诊断和治疗。
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