血清硒与心血管疾病预后：来自 AtheroGene 研究的结果。
Serum selenium and prognosis in cardiovascular disease: results from the AtheroGene study.
机构信息
Department of Medicine II, Johannes Gutenberg-University Mainz, Langenbeckstr. 1, Mainz, Germany.
出版信息
Atherosclerosis. 2010 Mar;209(1):271-7. doi: 10.1016/j.atherosclerosis.2009.09.008. Epub 2009 Sep 12.
Abstract
OBJECTIVE
Experimental data suggest a protective role of the essential trace element selenium against cardiovascular disease (CVD), whereas epidemiological data remains controversial. We aimed to investigate the impact of serum selenium concentration in patients presenting with stable angina pectoris (SAP) or acute coronary syndrome (ACS) on long term prognosis.
METHODS
Baseline selenium concentration was measured in 1731 individuals (852 with SAP, and 879 with ACS). During a median follow-up of 6.1 years, 190 individuals died from cardiovascular causes.
RESULTS
In those ACS patients who subsequently died of cardiac causes, selenium levels were lower compared to survivors (61.0microg/L versus 71.5microg/L; P<0.0001). In a fully adjusted model, patients in the highest tertile of selenium concentration had a hazard ratio of 0.38 (95% CI: 0.16-0.91; P=0.03) as compared with those in the lowest. No association between selenium levels and cardiovascular outcome was observed in SAP.
CONCLUSIONS
Low selenium concentration was associated with future cardiovascular death in patients with ACS.
摘要
目的
实验数据表明，必需微量元素硒对心血管疾病（CVD）具有保护作用，而流行病学数据仍存在争议。我们旨在研究稳定型心绞痛（SAP）或急性冠状动脉综合征（ACS）患者血清硒浓度对长期预后的影响。
方法
在 1731 名个体中测量了基线硒浓度（852 名 SAP 患者和 879 名 ACS 患者）。在中位数为 6.1 年的随访期间，有 190 人因心血管原因死亡。
结果
在随后因心脏原因死亡的 ACS 患者中，硒水平低于幸存者（61.0μg/L 与 71.5μg/L；P<0.0001）。在完全调整的模型中，与最低三分位组相比，硒浓度最高三分位组的风险比为 0.38（95%CI：0.16-0.91；P=0.03）。在 SAP 中未观察到硒水平与心血管结局之间存在关联。
结论
ACS 患者的低硒浓度与未来心血管死亡相关。
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