Welch Michael J, Hawker Craig J, Wooley Karen L
Department of Radiology, Washington University, Saint Louis, Missouri 63110, USA.
J Nucl Med. 2009 Nov;50(11):1743-6. doi: 10.2967/jnumed.109.061846. Epub 2009 Oct 16.
Nanoparticles have an advantage for molecular imaging in that many functionalities can be added to the surface and interior of the particle. This brief review focuses on the design of nanomaterials that take advantage of PET. An evolutionary approach is presented, leading to the optimization of the nanoparticle composition and structure to achieve controlled in vivo circulation and tissue-selective targeting. Organic and inorganic nanostructures are included. Nanoprobes for PET of angiogenesis and cancer are highlighted.
纳米颗粒在分子成像方面具有优势，因为可以在颗粒的表面和内部添加多种功能。本简要综述重点关注利用正电子发射断层扫描（PET）的纳米材料设计。提出了一种逐步演进的方法，以优化纳米颗粒的组成和结构，从而实现体内循环的可控性和组织选择性靶向。其中包括有机和无机纳米结构。重点介绍了用于血管生成和癌症PET成像的纳米探针。
