Immunomodulation Laboratory, Defense Institute of Physiology and Allied Sciences, Delhi, India.
Immunopharmacol Immunotoxicol. 2010 Mar;32(1):141-6. doi: 10.3109/08923970903503668.
In the present study we have evaluated the immunopotentiating activity of Rhodiola aqueous extract (RAE) in rats. The efficacy of RAE was determined by using strong antigen tetanus toxoid (TT) and weak antigen Ovalbumin (OVA). The dynamic changes in humoral and cell-mediated immune response were measured. The results indicated that the TT specific immunoglobulin levels were significantly enhanced by RAE and were at par with complete Freund's adjuvant (CFA). The level of OVA induced antibody response was also enhanced by RAE. It was observed that TT and OVA in combination with CFA or RAE could evoke a significant delayed type hypersensitivity (DTH) response, confirming its potential to generate strong cell-mediated immunity (CMI). The anti-inflammatory or immunosuppressive effect of RAE was evaluated in adjuvant-induced arthritis model (AIA). RAE could not suppress the swelling response. Therefore, this study suggests that RAE has adjuvant/immunopotentiating activity in terms of humoral as well as cell-mediated immune response against strong antigen like TT and weak antigen like OVA.
在本研究中，我们评估了红景天水提取物（RAE）在大鼠中的免疫增强活性。通过使用强抗原破伤风类毒素（TT）和弱抗原卵清蛋白（OVA）来确定 RAE 的功效。测量了体液和细胞介导的免疫反应的动态变化。结果表明，RAE 显著增强了 TT 特异性免疫球蛋白水平，与完全弗氏佐剂（CFA）相当。RAE 还增强了 OVA 诱导的抗体反应。观察到 TT 和 OVA 与 CFA 或 RAE 结合可引起显著的迟发型超敏反应（DTH）反应，证实其具有产生强细胞介导免疫（CMI）的潜力。在佐剂诱导的关节炎模型（AIA）中评估了 RAE 的抗炎或免疫抑制作用。RAE 不能抑制肿胀反应。因此，本研究表明，RAE 具有佐剂/免疫增强活性，可针对 TT 等强抗原和 OVA 等弱抗原产生体液和细胞介导的免疫反应。
