Immunomodulation laboratory, Defence Institute of Physiology and Allied Sciences, Timarpur, Delhi, India.
Immunopharmacol Immunotoxicol. 2012 Jun;34(3):513-8. doi: 10.3109/08923973.2011.638307. Epub 2012 Jan 13.
In the present study, we have evaluated the anti-cellular and immunomodulatory potential of aqueous extract of Rhodiola imbricata rhizome (RAE). Rhodiola extract inhibited the proliferation of human T cell lymphoma cell line EL-4 and erythroleukemic cell line HL-60. Furthermore, treatment of human peripheral blood mononuclear cells (hPBMCs) with lipopolysaccharide (LPS) and RAE suppressed regulated upon activation, normal T cell expressed and secreted (RANTES) production. However, number of TNF-α spots was increased in RAE treated hPBMCs. The reverse transcriptase polymerase chain reaction (RT-PCR) analysis of RAE treated rat splenocytes confirmed the up regulation of TLR-4 mRNA expression. Therefore, the present study concludes that RAE has potent immune boosting activity which might be useful in immunocompromised individuals.
在本研究中，我们评估了红景天根茎水提物（RAE）的抗细胞和免疫调节潜力。红景天提取物抑制人 T 细胞淋巴瘤细胞系 EL-4 和红白血病细胞系 HL-60 的增殖。此外，用脂多糖（LPS）和 RAE 处理人外周血单核细胞（hPBMC）抑制调节激活后正常 T 细胞表达和分泌（RANTES）的产生。然而，在 RAE 处理的 hPBMC 中 TNF-α 斑点的数量增加。用 RAE 处理的大鼠脾细胞的逆转录聚合酶链反应（RT-PCR）分析证实了 TLR-4 mRNA 表达的上调。因此，本研究得出结论，RAE 具有强大的免疫增强活性，可能对免疫功能低下的个体有用。
