Rosas-Ballina Mauricio, Tracey Kevin J
Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, North Shore-LIJ Health System, 350 Community Drive, Manhasset, NY 11030, USA.
Neuron. 2009 Oct 15;64(1):28-32. doi: 10.1016/j.neuron.2009.09.039.
Parallel advances in neuroscience and immunology established the anatomical and cellular basis for bidirectional interactions between the nervous and immune systems. Like other physiological systems, the immune system--and the development of immunity--is modulated by neural reflexes. A prototypical example is the inflammatory reflex, comprised of an afferent arm that senses inflammation and an efferent arm, the cholinergic anti-inflammatory pathway, that inhibits innate immune responses. This mechanism is dependent on the alpha7 subunit of the nicotinic acetylcholine receptor, which inhibits NF-kappaB nuclear translocation and suppresses cytokine release by monocytes and macrophages. Here we summarize evidence showing that innate immunity is reflexive. Future advances will come from applying an integrative physiology approach that utilizes methods adapted from neuroscience and immunology.
神经科学和免疫学的同步进展为神经和免疫系统之间的双向相互作用奠定了解剖学和细胞基础。与其他生理系统一样，免疫系统以及免疫的发育受到神经反射的调节。一个典型的例子是炎症反射，它由感知炎症的传入臂和传出臂（胆碱能抗炎途径）组成，该传出臂抑制先天免疫反应。这种机制依赖于烟碱型乙酰胆碱受体的α7亚基，它抑制NF-κB核转位并抑制单核细胞和巨噬细胞释放细胞因子。在这里，我们总结了表明先天免疫具有反射性的证据。未来的进展将来自应用整合生理学方法，该方法利用从神经科学和免疫学改编而来的方法。
