Kalyan Shirin, Chow Anthony W
Division of Infectious Diseases, Departments of Medicine, Microbiology and Immunology, University of British Columbia and Vancouver Hospital Coastal Health Research Institute, Vancouver, BC, Canada.
Mediators Inflamm. 2009;2009:819408. doi: 10.1155/2009/819408. Epub 2009 Oct 13.
gammadelta T cells play an important role in regulating the immune response to stress stimuli; however, the mean by which these innate lymphocytes fulfill this function remains poorly defined. The main subset of human peripheral blood gammadelta T cells responds to nonpeptidic antigens, such as isopentylpyrophosphate (IPP), a metabolite in the mevalonate pathway for both eukaryote and prokaryote cells. IPP-primed gammadelta T cells significantly augment the inflammatory response mediated by monocytes and alphabeta T cells to TSST-1, the staphylococcal superantigen that is the major causative agent of toxic shock syndrome. Here we show that the small pool of activated peripheral gammadelta T cells induces an early upregulation of CD40 on monocytes and the local release of High Mobility Group Box-1 (HMGB-1), the molecule designated as the late mediator of systemic inflammation. This finding provides a new basis for how gammadelta T cells may serve as influential modulators of both endogenous and exogenous stress stimuli.
γδ T细胞在调节对应激刺激的免疫反应中发挥重要作用；然而，这些固有淋巴细胞履行该功能的方式仍不清楚。人类外周血γδ T细胞的主要亚群对非肽类抗原作出反应，如焦磷酸异戊烯酯（IPP），这是真核细胞和原核细胞甲羟戊酸途径中的一种代谢产物。经IPP致敏的γδ T细胞显著增强单核细胞和αβ T细胞介导的对TSST-1（中毒性休克综合征的主要病原体——葡萄球菌超抗原）的炎症反应。我们在此表明，一小部分活化的外周γδ T细胞可诱导单核细胞上CD40的早期上调以及高迁移率族蛋白B1（HMGB-1，被认为是全身炎症的晚期介质）的局部释放。这一发现为γδ T细胞如何作为内源性和外源性应激刺激的有影响力的调节因子提供了新的依据。
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