Department of Biobehavioral Health, The Pennsylvania State University, University Park., Pennsylvania 16802, USA.
Am J Hum Biol. 2010 May-Jun;22(3):375-7. doi: 10.1002/ajhb.21003.
Using data from the first four waves of the OCTO-Twin study (twins 80 + years), the present study investigated the stability and change of genetic and environmental contributions to pulmonary function. Using a genetic simplex model, variance in peak expiratory flow (PEF) at each wave was decomposed into additive genetic and nonshared (specific) environmental factors. Additionally, this analysis distinguished the source of these influences, either from previous waves (transmissions) or from novel influences at each wave (innovations). At each time point (except wave 1), the genetic variance was due to genetic transmissions from prior time points. Conversely, the specific environmental variance in PEF at each time point was mainly due to environmental innovations. These results imply that genetic factors contribute to the stability of pulmonary function over time whereas environmental factors contribute to its change.
利用 OCTO-Twin 研究前四波（双胞胎 80 岁以上）的数据，本研究调查了肺功能的遗传和环境贡献的稳定性和变化。使用遗传单体模型，对每个波峰呼气流量 (PEF) 的方差进行分解，得到可加遗传和非共享（特定）环境因素。此外，该分析区分了这些影响的来源，要么来自先前的波（传递），要么来自每个波的新影响（创新）。在每个时间点（除了波 1），遗传方差是由于先前时间点的遗传传递所致。相反，每个时间点的 PEF 特定环境方差主要是由于环境创新所致。这些结果表明，遗传因素有助于肺功能随时间的稳定性，而环境因素则有助于其变化。
