Department of Materials Science and Engineering, Massachusetts Institute of Technology (MIT), 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
Small. 2010 Jan;6(1):12-21. doi: 10.1002/smll.200901158.
The interaction of nanomaterials with cells and lipid bilayers is critical in many applications such as phototherapy, imaging, and drug/gene delivery. These applications require a firm control over nanoparticle-cell interactions, which are mainly dictated by surface properties of nanoparticles. This critical Review presents an understanding of how synthetic and natural chemical moieties on the nanoparticle surface (in addition to nanoparticle shape and size) impact their interaction with lipid bilayers and cells. Challenges for undertaking a systematic study to elucidate nanoparticle-cell interactions are also discussed.
纳米材料与细胞和脂质双层的相互作用在许多应用中至关重要，例如光疗、成像和药物/基因传递。这些应用需要对纳米颗粒与细胞的相互作用进行严格控制，而这主要取决于纳米颗粒的表面特性。这篇重要的综述介绍了如何理解纳米颗粒表面的合成和天然化学基团（除了纳米颗粒的形状和尺寸外）如何影响它们与脂质双层和细胞的相互作用。还讨论了进行系统研究以阐明纳米颗粒与细胞相互作用的挑战。
