Larry Hillblom Islet Research Center, UCLA David Geffen School of Medicine, Los Angeles, CA 90024-2852, USA.
Diabetologia. 2010 Jan;53(1):111-4. doi: 10.1007/s00125-009-1552-z. Epub 2009 Oct 22.
AIMS/HYPOTHESIS: We sought to establish the relationship between fasting plasma glucose concentrations and pancreatic fractional beta cell area in adult cynomolgus monkeys (Macaca fascicularis).
Fasting plasma glucose and pancreatic fractional beta cell area were measured in 18 control and 17 streptozotocin-treated adult primates (17.0 +/- 1.2 vs 15.4 +/- 1.2 years old).
Fasting plasma glucose was increased (12.0 +/- 2.0 vs 3.4 +/- 0.1 mmol/l, p < 0.01) and fractional beta cell area was decreased (0.62 +/- 0.13% vs 2.49 +/- 0.35%, p < 0.01) in streptozotocin-treated monkeys. The relationship between fasting plasma glucose and pancreatic fractional beta cell area was described by a wide range of beta cell areas in controls. In streptozotocin-treated monkeys there was an inflection of fasting blood glucose at approximately 50% of the mean beta cell area in controls with a steep increase in blood glucose for each further decrement in beta cell area.
CONCLUSIONS/INTERPRETATION: In adult non-human primates a decrement in fractional beta cell area of approximately 50% or more leads to loss of glycaemic control.
目的/假设：我们旨在建立成年食蟹猴（Macaca fascicularis）空腹血浆葡萄糖浓度与胰岛β细胞面积分数之间的关系。
在 18 例对照和 17 例链脲佐菌素治疗的成年灵长类动物中测量空腹血浆葡萄糖和胰岛β细胞面积分数（17.0 +/- 1.2 岁与 15.4 +/- 1.2 岁）。
链脲佐菌素治疗的猴子空腹血浆葡萄糖升高（12.0 +/- 2.0 对 3.4 +/- 0.1 mmol/l，p < 0.01），β细胞面积分数降低（0.62 +/- 0.13% 对 2.49 +/- 0.35%，p < 0.01）。空腹血浆葡萄糖与胰岛β细胞面积分数之间的关系在对照组中有广泛的β细胞面积范围。在链脲佐菌素治疗的猴子中，空腹血糖在对照组β细胞面积平均值的约 50%处出现拐点，随着β细胞面积的进一步减少，血糖急剧升高。
结论/解释：在成年非人类灵长类动物中，β细胞面积分数下降约 50%或更多会导致血糖控制丧失。
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