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[药物性神经增强的选择、局限与伦理]

[Options, limits and ethics of pharmacological neuroenhancement].

作者信息

Normann C, Boldt J, Maio G, Berger M

机构信息

Abteilung Psychiatrie und Psychotherapie, Universitätsklinikum, Hauptstrasse 5, 79104 Freiburg.

出版信息

Nervenarzt. 2010 Jan;81(1):66-74. doi: 10.1007/s00115-009-2858-2.

DOI:10.1007/s00115-009-2858-2
PMID:19851745
Abstract

Pharmacological neuroenhancement is an attempt to increase cognitive performance in healthy humans. Learning and memory, attention and vigilance or mood and social interaction are targeted by a modulation of brain plasticity. Firstly, an analysis of the current state of research shows that, until now, clinical trials of neuroenhancing drugs have demonstrated only limited efficacy and long-term side effects remain largely unexplored. Secondly, we argue that, from an ethical perspective, neuroenhancement differs from socially mediated methods of learning. Pharmacological neuroenhancement is based on notions of efficacy and control that threaten to undermine other important aspects of mental capacities.

摘要

药理学神经增强是指试图提高健康人的认知能力。通过调节大脑可塑性来针对学习与记忆、注意力与警觉性或情绪与社交互动。首先,对当前研究现状的分析表明,到目前为止,神经增强药物的临床试验仅显示出有限的疗效,长期副作用在很大程度上仍未得到探索。其次,我们认为,从伦理角度来看,神经增强与社会介导的学习方法不同。药理学神经增强基于功效和控制的概念,这有可能破坏心理能力的其他重要方面。

相似文献

1
[Options, limits and ethics of pharmacological neuroenhancement].[药物性神经增强的选择、局限与伦理]
Nervenarzt. 2010 Jan;81(1):66-74. doi: 10.1007/s00115-009-2858-2.
2
Neuroenhancers, addiction and research ethics.神经增强剂、成瘾和研究伦理。
J Med Ethics. 2012 Oct;38(10):605-8. doi: 10.1136/medethics-2012-100616. Epub 2012 Aug 11.
3
Cognitive neuroenhancement: false assumptions in the ethical debate.认知神经增强:伦理辩论中的错误假设。
J Med Ethics. 2012 Jun;38(6):372-5. doi: 10.1136/medethics-2011-100041. Epub 2012 Jan 6.
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Neuroenhancement: status quo and perspectives.神经增强:现状与展望。
Eur Arch Psychiatry Clin Neurosci. 2008 Nov;258 Suppl 5:110-4. doi: 10.1007/s00406-008-5022-2.
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Brain gain: the underground world of neuroenhancing drugs.脑力获取:神经增强药物的隐秘世界
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6
Accelerating human evolution.
Pharos Alpha Omega Alpha Honor Med Soc. 2009 Summer;72(3):1.
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True and false concerns about neuroenhancement: a response to 'Neuroenhancers, addiction and research ethics', by D M Shaw.关于神经增强的真假担忧:对D·M·肖所著《神经增强剂、成瘾与研究伦理》的回应
J Med Ethics. 2014 Apr;40(4):286-7. doi: 10.1136/medethics-2013-101317. Epub 2013 Mar 6.
8
Accelerating human evolution??
Pharos Alpha Omega Alpha Honor Med Soc. 2010 Winter;73(1):48.
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Accelerating human evolution??加速人类进化??
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Better evidence for safety and efficacy is needed before neurologists prescribe drugs for neuroenhancement to healthy people.在神经科医生给健康人开用于神经增强的药物之前,需要有更好的安全性和有效性证据。
Neurocase. 2012 Jun;18(3):181-4. doi: 10.1080/13554794.2011.588174. Epub 2011 Oct 18.

引用本文的文献

1
Pharmacological Neuroenhancement: Current Aspects of Categorization, Epidemiology, Pharmacology, Drug Development, Ethics, and Future Perspectives.药理学神经增强:分类、流行病学、药理学、药物开发、伦理学的当前方面和未来展望。
Neural Plast. 2021 Jan 13;2021:8823383. doi: 10.1155/2021/8823383. eCollection 2021.
2
Evaluating the drivers of and obstacles to the willingness to use cognitive enhancement drugs: the influence of drug characteristics, social environment, and personal characteristics.评估使用认知增强药物的意愿的驱动因素和障碍:药物特征、社会环境和个人特征的影响。
Subst Abuse Treat Prev Policy. 2014 Feb 1;9:8. doi: 10.1186/1747-597X-9-8.

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