Faculty of Pharmacy, Medicinal Plants Research Center, Medical Sciences/University of Tehran, Tehran, Iran.
Nat Prod Res. 2009;23(17):1609-14. doi: 10.1080/14786410902800707.
From the ethyl acetate and methanol extract of the aerial parts of Satureja atropatana Bonge, which belongs to the Lamiaceae family, four flavonoids were isolated. Their structures were determined to be 5,6,3'-trihydroxy-7,8,4'-trimethoxyflavone (1), 5,6-dihydroxy-7,8,3',4'-tetramethoxyflavone or 5-desmethoxynobiletin (2), 5,6,4'-trihydroxy-7,8,3'-trimethoxyflavone or thymonin (3) and luteolin (4) using (1)H and (13)C-NMR and MS spectra. Brine shrimp cytotoxicity effects of the crude extracts and isolated compounds were examined. Berberine hydrochloride (LC(50) = 26 microg mL(-1)) was used as a positive control. Among them, compounds 2 (199 microg mL(-1)) and 3 (157 microg mL(-1)) were effective against Artemia salina larva.
从唇形科植物野荆芥（Satureja atropatana Bonge）的地上部分的乙酸乙酯和甲醇提取物中分离得到了四种黄酮类化合物。它们的结构被确定为 5,6,3'-三羟基-7,8,4'-三甲氧基黄酮（1）、5,6-二羟基-7,8,3',4'-四甲氧基黄酮或 5-去甲氧基诺卜他林（2）、5,6,4'-三羟基-7,8,3'-三甲氧基黄酮或胸腺嘧啶（3）和木犀草素（4），使用（1）H 和（13）C-NMR 和 MS 光谱。测试了粗提取物和分离化合物对盐水虾的细胞毒性作用。盐酸小檗碱（LC（50）= 26 μg mL（-1））被用作阳性对照。其中，化合物 2（199 μg mL（-1））和 3（157 μg mL（-1））对卤虫幼虫有效。
