Dipartimento di Chimica delle Sostanze Naturali, Universita di Napoli "Federico II", via D. Montesano, 49, 80131 Napoli, Italy.
Chem Res Toxicol. 2009 Nov;22(11):1851-9. doi: 10.1021/tx900259v.
This paper reports on the analysis of the toxin content from Palythoa tuberculosa and Palythoa toxica samples collected off of the Hawaiian coast. Our work, based on in-depth high-resolution liquid chromatography-mass spectrometry analysis along with extensive NMR study, led us to structurally characterize 42-hydroxy-palytoxin, a new palytoxin congener. This toxin and palytoxin itself appeared to be the major components of toxic extract from a P. tuberculosa sample, while 42-hydroxy-palytoxin was proven by far to be the main palytoxin derivative in P. toxica. Functional studies on this new palytoxin-like compound suggest that the new palytoxin analogue and palytoxin itself present similar biological activities.
本文报告了对采集自夏威夷海岸的石莼属（Palythoa）毒蕈珊瑚和毒丝珊瑚样本中的毒素含量进行的分析。我们的工作基于深入的高分辨率液相色谱-质谱分析以及广泛的 NMR 研究，成功对 42-羟基石房蛤毒素进行了结构表征，这是一种新的石房蛤毒素同系物。该毒素和石房蛤毒素本身似乎是来自石莼属（Palythoa）毒蕈珊瑚样本的有毒提取物的主要成分，而 42-羟基石房蛤毒素则被证明是毒丝珊瑚中主要的石房蛤毒素衍生物。对这种新型的石房蛤毒素类似物的功能研究表明，这种新型的石房蛤毒素类似物和石房蛤毒素本身具有相似的生物学活性。
