Ottoni Claudio, Martinez-Labarga Cristina, Vitelli Luciana, Scano Giuseppina, Fabrini Enrico, Contini Irene, Biondi Gianfranco, Rickards Olga
Department of Biology, University of Rome 'Tor Vergata' Via della Ricerca Scientifica, n. 1, 00173, Rome, Italy.
Ann Hum Biol. 2009 Nov-Dec;36(6):785-811. doi: 10.3109/03014460903198509.
Since prehistoric times Southern Italy has been a cultural crossroads of the Mediterranean basin. Genetic data on the peoples of Basilicata and Calabria are scarce and, particularly, no records on mtDNA variability have been published.
In this study mtDNA haplotypes of populations from Basilicata, Calabria and Sicily are compared with those of other Italian and Mediterranean populations, so as to investigate their genetic relationships.
A total of 341 individuals was analysed for mtDNA in order to provide their classification into haplogroups. Multivariate analysis was used to compare the studied populations with other Mediterranean samples; median-joining network analysis was applied to observe the relationship between the major lineages of the Southern Italians.
The haplogroup distribution in the Southern Italian samples falls within the typical pattern of mtDNA variability of Western Eurasia. The comparison with other Mediterranean countries showed a substantial homogeneity of the area, which is probably related to the historic contact through the Mediterranean Sea.
The mtDNA analysis demonstrated that Southern Italy displays a typical pattern of Mediterranean basin variability, even though it appears plausible that Southern Italy was less affected by the effects of the Late Glacial Maximum, which reduced genetic diversity in Europe.
自史前时代以来，意大利南部一直是地中海盆地的文化十字路口。关于巴西利卡塔和卡拉布里亚地区人群的基因数据稀少，特别是关于线粒体DNA（mtDNA）变异性的记录尚未发表。
在本研究中，将巴西利卡塔、卡拉布里亚和西西里岛人群的mtDNA单倍型与其他意大利和地中海人群的进行比较，以研究它们的遗传关系。
共分析了341人的mtDNA，以便将他们分类到单倍群中。采用多变量分析将研究人群与其他地中海样本进行比较；应用中位数连接网络分析来观察意大利南部主要谱系之间的关系。
意大利南部样本中的单倍群分布属于西亚西部典型的mtDNA变异模式。与其他地中海国家的比较显示该地区具有显著的同质性，这可能与通过地中海的历史联系有关。
mtDNA分析表明，意大利南部呈现出地中海盆地典型的变异模式，尽管意大利南部似乎较少受到末次盛冰期影响，末次盛冰期降低了欧洲的遗传多样性，这一点似乎是合理的。
