Guedes R A Paletta, Guedes V M Paletta, Chaoubah A
Paletta Guedes Ophthalmic Center, Juiz de Fora, MG, Brazil.
J Fr Ophtalmol. 2009 Nov;32(9):640-5. doi: 10.1016/j.jfo.2009.09.003. Epub 2009 Oct 24.
To assess the results of a pilot study for screening high-risk individuals for glaucoma in Brazil.
Using cross-sectional methodology, the study population consisted of first-degree relatives of known glaucoma patients. Risk factors were assessed through a questionnaire, and each subject received a complete eye examination.
Sixty individuals were identified and examined. The most relevant risk factors for glaucoma were: age older than 40 years (86.7%), systemic hypertension (46.7%), and self-identification as non-white (35%). Final diagnoses were normal (63.3%), glaucoma (23.3%), ocular hypertension (11.7%), and angle-closure without glaucoma (1.7%). Clinical features that were significant as an indicator of glaucoma presence were non-white participants (OR=6.7, p=0.004), central corneal thickness < 520 microm (OR=6.286, p=0.007), and cup-to-disc ratio >or= 0.6 (OR=3.00, p=0.07).
Despite our study's small sample size, this high prevalence of glaucoma (23.3%) highlights the importance of identifying for screening at-risk, first-degree relatives of glaucoma patients. Pachymetry was an important diagnostic tool for glaucoma within this population.
评估在巴西对青光眼高危个体进行筛查的一项初步研究结果。
采用横断面研究方法，研究人群包括已知青光眼患者的一级亲属。通过问卷评估危险因素，每位受试者接受全面的眼部检查。
共识别并检查了60名个体。青光眼最相关的危险因素为：年龄大于40岁（86.7%）、系统性高血压（46.7%）以及自我认定为非白人（35%）。最终诊断结果为正常（63.3%）、青光眼（23.3%）、高眼压症（11.7%）以及无青光眼的闭角型青光眼（1.7%）。作为青光眼存在指标具有显著意义的临床特征为非白人参与者（比值比=6.7，p=0.004）、中央角膜厚度<520微米（比值比=6.286，p=0.007）以及杯盘比≥0.6（比值比=3.00，p=0.07）。
尽管本研究样本量较小，但青光眼的高患病率（23.3%）凸显了识别青光眼患者高危一级亲属进行筛查的重要性。在该人群中，角膜测厚是青光眼的一项重要诊断工具。
