Umulis David, O'Connor Michael B, Blair Seth S
Department of Agricultural and Biological Engineering, Purdue University, IN 47907, USA.
Development. 2009 Nov;136(22):3715-28. doi: 10.1242/dev.031534.
In many cases, the level, positioning and timing of signaling through the bone morphogenetic protein (BMP) pathway are regulated by molecules that bind BMP ligands in the extracellular space. Whereas many BMP-binding proteins inhibit signaling by sequestering BMPs from their receptors, other BMP-binding proteins cause remarkably context-specific gains or losses in signaling. Here, we review recent findings and hypotheses on the complex mechanisms that lead to these effects, with data from developing systems, biochemical analyses and mathematical modeling.
在许多情况下，通过骨形态发生蛋白（BMP）信号通路进行信号传导的水平、定位和时间是由细胞外空间中结合BMP配体的分子调节的。虽然许多BMP结合蛋白通过将BMP与它们的受体隔离来抑制信号传导，但其他BMP结合蛋白会在信号传导中导致显著的上下文特异性增加或减少。在这里，我们结合来自发育系统、生化分析和数学建模的数据，综述了关于导致这些效应的复杂机制的最新发现和假说。
