Sedlmeier Georg, Sleeman Jonathan P
Centre for Biomedicine and Medical Technology Mannheim, Medical Faculty Mannheim, University Heidelberg, 68167 Mannheim, Germany
Institute for Toxicology and Genetics, Karlsruhe Institute of Technology Campus Nord, 76021 Karlsruhe, Germany.
Biochem Soc Trans. 2017 Feb 8;45(1):173-181. doi: 10.1042/BST20160263.
Given its importance in development and homeostasis, bone morphogenetic protein (BMP) signaling is tightly regulated at the extra- and intracellular level. The extracellular matrix (ECM) was initially thought to act as a passive mechanical barrier that sequesters BMPs. However, a new understanding about how the ECM plays an instructive role in regulating BMP signaling is emerging. In this mini-review, we discuss various ways in which the biochemical and physical properties of the ECM regulate BMP signaling.
鉴于骨形态发生蛋白（BMP）信号在发育和体内平衡中的重要性，其在细胞外和细胞内水平受到严格调控。细胞外基质（ECM）最初被认为是一种隔离BMP的被动机械屏障。然而，关于ECM如何在调节BMP信号中发挥指导作用的新认识正在浮现。在本综述中，我们讨论了ECM的生化和物理特性调节BMP信号的各种方式。
