Massachusetts General Hospital, Boston, MA 02114, USA.
Psychosomatics. 2009 Sep-Oct;50(5):448-54. doi: 10.1176/appi.psy.50.5.448.
Depressive symptoms are common in Parkinson's disease (PD); however, it is unclear whether there are specific depressive symptom patterns in patients with PD and comorbid depression (dPD).
The goal of this study is to examine the frequency and correlates of specific depressive symptoms in PD.
A sample of 158 individuals with PD completed the self-rated Harvard Department of Psychiatry/National Depression Screening Day Scale (HANDS). By multiple-regression analysis, the authors examined the association between HANDS total and subscale scores and various demographic variables.
The frequency of depression was 37% (N=58). Patients with a history of depression before PD had significantly more serious depression than those who had no such history. Of those who were more depressed, the most common symptoms of depression endorsed were low energy, difficulty with concentration/making decisions, feeling blue, feeling hopeless, and having poor sleep.
There is a relatively high prevalence of dPD. Items on the HANDS that discriminated best between depressed and nondepressed subjects with PD included feeling blue, feeling hopeless, feeling worthless, lack of interest, and self-blame. It remains to be defined whether dPD should be understood primarily as a psychological reaction to a physical disability or perceived impending one, or as a direct expression of the neuropathology of PD.
抑郁症状在帕金森病（PD）中很常见；然而，尚不清楚 PD 合并抑郁（dPD）患者是否存在特定的抑郁症状模式。
本研究旨在探讨 PD 患者中特定抑郁症状的发生频率及相关因素。
158 名 PD 患者完成了自评哈佛精神病学系/国家抑郁筛查日量表（HANDS）。通过多元回归分析，作者探讨了 HANDS 总分和分量表评分与各种人口统计学变量之间的关联。
抑郁的发生率为 37%（N=58）。有 PD 前抑郁史的患者比没有这种病史的患者抑郁程度明显更严重。在那些抑郁程度更严重的患者中，最常见的抑郁症状包括精力不足、注意力集中/决策困难、感到忧郁、感到绝望和睡眠不佳。
dPD 的患病率相对较高。在区分 PD 伴抑郁和不伴抑郁患者方面，HANDS 表现最佳的项目包括忧郁感、绝望感、无价值感、缺乏兴趣和自责。dPD 是否应主要被理解为对身体残疾或预期残疾的心理反应，还是 PD 神经病理学的直接表现，仍有待进一步定义。
