Department of Medical Physics, Ninewells Hospital, NHS Tayside, Dundee, UK.
J Magn Reson Imaging. 2009 Nov;30(5):1059-67. doi: 10.1002/jmri.21930.
To optimize the contrast agent dose and delivery rate used in a novel whole-body magnetic resonance angiography (MRA) protocol using a 3.0T MR scanner.
Six groups of 20 consenting volunteers underwent whole-body MRA, with each group receiving a different contrast dose and contrast delivery rate. The arterial tree was divided into 16 segments and the image quality at each of the anatomical locations, covering the whole body, was assessed. Qualitative analysis was carried out using a scoring assessment of image quality, and quantitative assessments were performed by measuring contrast-to-noise (CNR) and a signal-to-noise (SNR) index.
Reducing the contrast dose from 40 mL to 25 mL was found to significantly increase the CNR in several vessels of interest in the arterial tree. There was also a significant increase in the qualitative image quality score (P < 0.001).
This study demonstrates that reducing the contrast dose at 3.0T can result in an increase in the CNR in the vessels of interest without significantly affecting the SNR.
使用 3.0T MR 扫描仪优化新型全身磁共振血管造影（MRA）方案中使用的对比剂剂量和输送率。
六组 20 名同意的志愿者接受了全身 MRA，每组接受不同的对比剂量和对比输送率。将动脉树分为 16 个节段，并评估覆盖全身的每个解剖位置的图像质量。使用图像质量评分的定性分析进行定性分析，通过测量对比噪声比（CNR）和信噪比（SNR）指数进行定量评估。
从 40 毫升减少到 25 毫升的对比剂剂量被发现显著增加了动脉树中几个感兴趣血管的 CNR。定性图像质量评分也显著增加（P < 0.001）。
本研究表明，在 3.0T 下降低对比剂剂量可以增加感兴趣血管的 CNR，而不会显著影响 SNR。
