Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany.
J Magn Reson Imaging. 2009 Nov;30(5):1163-70. doi: 10.1002/jmri.21946.
To measure longitudinal relaxation rate (R1) changes during contrast agent studies using a driven equilibrium single pulse observation of T1 (DESPOT) method with a sliding window (sw) acquisition.
A sw-DESPOT technique was implemented that uses several three-dimensional (3D) image data sets to calculate R1 with a temporal resolution of only a single data set. Different sources of systematic errors were studied in simulations, and the technique was tested in a tumor-bearing mouse using an intravascular contrast agent.
Consistent concentration distributions of the CA were calculated with a temporal resolution of 10 s.
Sw-DESPOT offers a precise and fast method to monitor the CA dynamics in 3D volumes.
使用带有滑动窗口（sw）采集的驱动平衡单次脉冲观察 T1（DESPOT）方法测量对比剂研究期间的纵向弛豫率（R1）变化。
实现了 sw-DESPOT 技术，该技术使用多个三维（3D）图像数据集仅使用单个数据集计算 R1，具有时间分辨率。在模拟中研究了不同的系统误差源，并使用血管内对比剂在荷瘤小鼠中对该技术进行了测试。
以 10 秒的时间分辨率计算出 CA 的一致浓度分布。
sw-DESPOT 提供了一种精确且快速的方法来监测 3D 体积中的 CA 动力学。
