Núcleo de Pesquisas em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
Nutrition. 2010 Jul-Aug;26(7-8):804-10. doi: 10.1016/j.nut.2009.09.007. Epub 2009 Dec 22.
We investigated the antioxidant potential and hypocholesterolemic effects of acai (Euterpe oleracea Mart.) pulp ingestion in rats fed a standard or hypercholesterolemic diet.
Female Fischer rats were fed a standard AIN-93 M diet (control) or a hypercholesterolemic diet that contained 25% soy oil and 1% cholesterol. The test diet was supplemented with 2% acai pulp (dry wt/wt) for control (group CA) and hypercholesterolemic rats (group HA) for 6 wk. At the end of the experimental period, rats were sacrificed and the blood and livers were collected. To evaluate the effect of acai consumption, levels of protein carbonyl and sulfhydryl groups, superoxide dismutase and paraoxonase activities, and lipid profiles of the sera were measured.
Animals that were fed the hypercholesterolemic diet presented increased levels of total and non-high-density lipoprotein cholesterol and decreased levels of high-density lipoprotein cholesterol. Supplementing the diet of this group with acai caused a hypocholesterolemic effect by reducing total and non-high-density lipoprotein cholesterol. Serum levels of carbonyl proteins and total, free, and protein sulfhydryl groups were reduced by acai ingestion in animals receiving the standard or hypercholesterolemic diet. Acai supplementation induced a significant reduction in superoxide dismutase activity only in the hypercholesterolemic rats, indicating an association between diet and acai treatment. Also, acai supplementation increased paraoxonase activity in the CA and HA groups.
These results suggest that the consumption of acai improves antioxidant status and has a hypocholesterolemic effect in an animal model of dietary-induced hypercholesterolemia.
研究在给予标准或高胆固醇饮食的大鼠中摄入阿萨伊（Euterpe oleracea Mart.）果肉的抗氧化潜力和降胆固醇作用。
雌性 Fischer 大鼠喂食标准 AIN-93 M 饮食（对照）或含有 25%大豆油和 1%胆固醇的高胆固醇饮食。对照（CA 组）和高胆固醇（HA 组）大鼠的测试饮食分别补充 2%阿萨伊果肉（干重/重量）6 周。在实验期末，处死大鼠并采集血液和肝脏。为了评估阿萨伊消费的效果，测量了血清中蛋白质羰基和巯基基团、超氧化物歧化酶和对氧磷酶活性以及脂质谱的水平。
喂食高胆固醇饮食的动物表现出总胆固醇和非高密度脂蛋白胆固醇水平升高，而高密度脂蛋白胆固醇水平降低。在该组饮食中补充阿萨伊导致总胆固醇和非高密度脂蛋白胆固醇降低，从而产生降胆固醇作用。在接受标准或高胆固醇饮食的动物中，阿萨伊摄入降低了血清羰基蛋白和总、游离和蛋白质巯基基团的水平。阿萨伊补充仅在高胆固醇大鼠中诱导超氧化物歧化酶活性显著降低，表明饮食和阿萨伊治疗之间存在关联。此外，阿萨伊补充增加了 CA 和 HA 组的对氧磷酶活性。
这些结果表明，阿萨伊的摄入改善了抗氧化状态，并在饮食诱导的高胆固醇血症动物模型中具有降胆固醇作用。
