Medicine College, Altamira Campus, Federal University of Pará (UFPA), Altamira 68372-040, PA, Brazil.
Laboratory of Molecular Pharmacology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil.
Nutrients. 2023 Jul 19;15(14):3189. doi: 10.3390/nu15143189.
The genus (mainly Martius, Martius, and Martius) has recently gained commercial and scientific notoriety due to the high nutritional value of its fruits, which are rich in polyphenols (phenolic acids and anthocyanins) and have potent antioxidant activity. These characteristics have contributed to the increased number of neuropharmacological evaluations of the three species over the last 10 years, especially açaí of the species Martius. The fruits of the three species exert neuroprotective effects through the modulation of inflammatory and oxidative pathways and other mechanisms, including the inhibition of the mTOR pathway and protection of the blood-brain barrier, all of them intimately involved in several neuropathologies. Thus, a better understanding of the neuropharmacological properties of these three species may open new paths for the development of therapeutic tools aimed at preventing and treating a variety of neurological conditions.
由于其果实具有高营养价值，富含多酚（酚酸和花青素），具有很强的抗氧化活性，该属（主要为 Martius、Martius 和 Martius）最近在商业和科学上引起了关注。这些特性促使人们在过去 10 年中对这三个物种进行了越来越多的神经药理学评估，特别是品种为 Martius 的巴西莓。这三个物种通过调节炎症和氧化途径以及其他机制（包括抑制 mTOR 途径和保护血脑屏障）发挥神经保护作用，所有这些都与几种神经病理学密切相关。因此，更好地了解这三个物种的神经药理学特性可能为开发治疗工具开辟新途径，以预防和治疗各种神经疾病。
