Department of Dermatology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Kaohsiung J Med Sci. 2009 Nov;25(11):622-7. doi: 10.1016/S1607-551X(09)70567-4.
Pemphigus vulgaris is a life-threatening autoimmune bullous dermatosis and its management represents a major challenge to medical teams. The primary treatments for pemphigus vulgaris are oral steroids and immunosuppressants, but topical approaches also play a role in disease management. Here, we report a patient with pemphigus vulgaris involving 62% of the total body surface area, with initial poor clinical response to systemic steroids and topical silver sulfadiazine therapy. However, a marked improvement in wound healing and decreased patient discomfort were observed after application of silver-containing hydrofiber dressings (Aquacel-Ag). Therefore, silver-containing hydrofiber dressings may offer an effective adjunct in the treatment of patients with pemphigus vulgaris with extensive skin involvement. Our encouraging experience with these dressing patches may be extended to manage other large exudation wounds.
寻常型天疱疮是一种危及生命的自身免疫性大疱性皮肤病，其治疗对医疗团队来说是一个重大挑战。寻常型天疱疮的主要治疗方法是口服类固醇和免疫抑制剂，但局部治疗方法在疾病管理中也发挥着作用。在这里，我们报告了一例寻常型天疱疮患者，其受累面积占体表面积的 62%，最初对全身类固醇和局部磺胺嘧啶银治疗反应不佳。然而，在使用含银水胶体纤维敷料（Aquacel-Ag）后，伤口愈合明显改善，患者不适感减轻。因此，含银水胶体纤维敷料在治疗广泛皮肤受累的寻常型天疱疮患者中可能是一种有效的辅助治疗方法。我们使用这些敷贴的经验令人鼓舞，可能会扩展到其他大渗出伤口的治疗。
