Caruso Daniel M, Foster Kevin N, Blome-Eberwein Sigri A, Twomey John A, Herndon David N, Luterman Arnold, Silverstein Paul, Antimarino Jeffrey R, Bauer Gregory J
Arizona Burn Center, Phoenix, Arizona 85008, USA.
J Burn Care Res. 2006 May-Jun;27(3):298-309. doi: 10.1097/01.BCR.0000216741.21433.66.
This prospective, randomized study compared protocols of care using either AQUACEL Ag Hydrofiber (ConvaTec, a Bristol-Myers Squibb company, Skillman, NJ) dressing with silver (n = 42) or silver sulfadiazine (n = 42) for up to 21 days in the management of partial-thickness burns covering 5% to 40% body surface area (BSA). AQUACEL Ag dressing was associated with less pain and anxiety during dressing changes, less burning and stinging during wear, fewer dressing changes, less nursing time, and fewer procedural medications. Silver sulfadiazine was associated with greater flexibility and ease of movement. Adverse events, including infection, were comparable between treatment groups. The AQUACEL Ag dressing protocol tended to have lower total treatment costs (Dollars 1040 vs. Dollars 1180) and a greater rate of re-epithelialization (73.8% vs 60.0%), resulting in cost-effectiveness per burn healed of Dollars 1,409.06 for AQUACEL Ag dressing and Dollars 1,967.95 for silver sulfadiazine. A protocol of care with AQUACEL(R) Ag provided clinical and economic benefits compared with silver sulfadiazine in patients with partial-thickness burns.
这项前瞻性随机研究比较了使用含银的爱康肤银水胶体敷料（康乐保公司，百时美施贵宝公司旗下，新泽西州斯基尔曼）（n = 42）或磺胺嘧啶银（n = 42）治疗体表面积5%至40%的浅度烧伤长达21天的护理方案。爱康肤银敷料在换药时疼痛和焦虑程度较低，使用时灼痛和刺痛较少，换药次数较少，护理时间较短，程序性用药较少。磺胺嘧啶银则具有更大的灵活性和活动便利性。包括感染在内的不良事件在治疗组之间相当。爱康肤银敷料方案的总治疗成本往往较低（1040美元对1180美元），上皮再形成率更高（73.8%对60.0%），爱康肤银敷料每治愈一处烧伤的成本效益为1409.06美元，磺胺嘧啶银为1967.95美元。与磺胺嘧啶银相比，爱康肤银护理方案为浅度烧伤患者带来了临床和经济效益。
