Dudvarski-Ilić Aleksandra, Mihailović-Vucinić Violeta, Gvozdenović Branislav, Zugić Vladimir, Milenković Branislava, Ilić Vladislav
Institute for Lung Diseases and TB, University Clinical Center of Serbia, Belgrade, Serbia.
Coll Antropol. 2009 Sep;33(3):837-40.
Evaluation of the health-related quality of life (HRQoL) in patients with respiratory diseases has been increasingly included into regular clinical studies, and HRQL in sarcoidosis has been evaluated since not a long ago. The aim of the study was to evaluate HRQoL in patients with sarcoidosis regarding gender differences, pre and after therapy. We investigated 202 pathohistologically verified sarcoidosis patients (154 female and 48 male) without comorbidities. HRQL was assessed by the disease-specific Sarcoidosis Health Questionnaire (SHQ), which contains 29 items, and cover three domains: everyday functioning, physical activities and emotional state. Total score, as well as the scores for each SHQ domains were calculated. HRQoL was estimated pre and after three months of therapy. At the study start, the lowest score value for the whole group was reported in SHQ emotional state domain (4.24), and the highest in domain of physical functioning (4.7). After three months, the lowest values were reported in domain of everyday activities, while the highest scores were found in emotional domain; all SHQ scores increased, but reached the statistical significance only in the everyday functioning and the physical activities domains. Analyzing mean SHQ scores in male and female sarcoidosis pts before therapy we found high statistically lower emotional and total score in female pts, as well as lower physical score. After the three months therapy we found high statistical difference in physical domain (i.e. women had lower physical score than men). Female sarcoidosis pts showed lower emotional, physical and total score before therapy. After the three-month therapy we found that women had lower physical score than men. SHQ showed good measurement properties both in the cross-sectional and longitudinal assessment of sarcoidosis patients.
对呼吸系统疾病患者健康相关生活质量（HRQoL）的评估已越来越多地纳入常规临床研究，结节病患者的HRQL评估也开展不久。本研究的目的是评估结节病患者在治疗前后的HRQoL性别差异。我们调查了202例经病理组织学证实且无合并症的结节病患者（154例女性和48例男性）。通过特定疾病的结节病健康问卷（SHQ）评估HRQL，该问卷包含29个项目，涵盖三个领域：日常功能、身体活动和情绪状态。计算总分以及每个SHQ领域的得分。在治疗三个月前后评估HRQoL。研究开始时，全组在SHQ情绪状态领域的得分最低（4.24），在身体功能领域得分最高（4.7）。三个月后，日常活动领域得分最低，而情绪领域得分最高；所有SHQ得分均有所增加，但仅在日常功能和身体活动领域达到统计学显著性。分析治疗前男性和女性结节病患者的平均SHQ得分，我们发现女性患者的情绪和总分在统计学上显著较低，身体得分也较低。三个月治疗后，我们发现在身体领域存在高度统计学差异（即女性的身体得分低于男性）。女性结节病患者在治疗前情绪、身体和总分较低。三个月治疗后，我们发现女性的身体得分低于男性。SHQ在结节病患者的横断面和纵向评估中均显示出良好的测量特性。
