Green Lane Respiratory Services, Auckland City Hospital, Auckland, New Zealand.
Respirology. 2012 Apr;17(3):519-24. doi: 10.1111/j.1440-1843.2012.02134.x.
Sarcoidosis is a multi-system disease with an unpredictable course and variable clinical manifestations that are often associated with impaired quality of life. The Sarcoidosis Health Questionnaire (SHQ), which was developed for an 80% African American population, assesses health-related quality of life in sarcoidosis patients. The aim of this study was to validate the SHQ in a predominantly European population of sarcoidosis patients.
Consecutive outpatients (n = 92) with sarcoidosis, who were attending a teaching hospital clinic, completed three questionnaires (SHQ, Short Form (SF) 36, Fatigue Assessment Scale (FAS)) and pulmonary function tests were performed.
The mean age of the patients was 51 years, 52% were males and 74% were of European ethnicity. The mean number of organs involved was 1.3, with pulmonary involvement in 95% of patients (mean forced expiratory volume in 1 s 74.4%, forced vital capacity 84.6%). Seventy percent of patients had current symptoms and 26.5% were receiving immunosuppressant therapy. The SHQ total score (mean 5.13) was significantly correlated with the SF 36 physical component score (46.7, r = 0.78) and the FAS (20.8, r = -0.7) but only weakly correlated with pulmonary function. There were significant differences in SHQ scores when patients were stratified according to symptoms, oral therapy, health status (P < 0.0001 for all), forced expiratory volume in 1 s ≥70% (P = 0.008) and forced vital capacity ≥70% (P = 0.01).
The SHQ correlated well with health-related quality of life and fatigue measures in a predominantly European population of sarcoidosis patients, despite differences in organ involvement and disease burden, when compared with the development study.
结节病是一种多系统疾病，其病程不可预测，临床表现多样，常伴有生活质量受损。Sarcoidosis Health Questionnaire（SHQ）是专为 80%非裔美国人人群开发的，用于评估结节病患者的健康相关生活质量。本研究旨在验证 SHQ 在以欧洲裔为主的结节病患者人群中的适用性。
连续就诊于教学医院门诊的结节病患者（n=92）完成了 3 份问卷（SHQ、Short Form（SF）36、疲劳评估量表（FAS））并进行了肺功能测试。
患者的平均年龄为 51 岁，52%为男性，74%为欧洲裔。平均受累器官数为 1.3 个，95%的患者有肺部受累（平均 1 秒用力呼气量 74.4%，用力肺活量 84.6%）。70%的患者有当前症状，26.5%正在接受免疫抑制剂治疗。SHQ 总分（平均 5.13）与 SF 36 生理成分评分（46.7，r=0.78）和 FAS（20.8，r=-0.7）显著相关，但与肺功能仅弱相关。根据症状、口服治疗、健康状况对患者进行分层时，SHQ 评分存在显著差异（均 P<0.0001），用力呼气量≥70%（P=0.008）和用力肺活量≥70%（P=0.01）的患者间存在差异。
尽管受累器官和疾病负担存在差异，但与开发研究相比，SHQ 与以欧洲裔为主的结节病患者的健康相关生活质量和疲劳测量结果相关性良好。
