The Department of Medical Oncology, British Columbia Cancer Agency, Vancouver, Canada.
Virchows Arch. 2009 Dec;455(6):477-83. doi: 10.1007/s00428-009-0834-7. Epub 2009 Oct 28.
Five cases of an unusual encapsulated apocrine papillary tumour are reported. All presented as cystic masses in the breast of women aged 44-84 years. Imaging studies showed a complex cyst often with one or more mural nodules. The key histological features are similar to those of classical encapsulated papillary carcinoma in that myoepithelial cells were absent within the papillary structures and at the periphery of the cyst. All were pure apocrine in type and showed variable degrees of cytological atypia and mitotic activity. All lacked evidence of malignancy in the breast tissue outside of the lesion. Sentinel lymph node biopsies performed in three of the cases were negative for metastases, and all have behaved in a benign fashion.
报告了 5 例不常见的囊状大汗腺乳头状瘤。所有患者均为 44-84 岁女性乳房中的囊性肿块。影像学研究显示复杂囊肿，常有一个或多个壁结节。主要组织学特征与经典囊状乳头状癌相似，即在乳头状结构内和囊肿边缘没有肌上皮细胞。所有肿瘤均为纯大汗腺型，具有不同程度的细胞学异型性和有丝分裂活性。所有肿瘤在病变外的乳腺组织中均无恶性证据。对其中 3 例进行了前哨淋巴结活检，均未见转移，且所有肿瘤均表现为良性。
