Tamási Lilla, Bohács Anikó, Bikov András, Andorka Csilla, Rigó János, Losonczy György, Horváth Ildikó
Department of Pulmonology, Semmelweis University, Budapest, Hungary.
J Asthma. 2009 Oct;46(8):786-91. doi: 10.1080/02770900903090004.
Measurement of fractioned exhaled nitric oxide (FE(NO)) is useful for monitoring airway inflammation in asthma. Asthma is one of the most common diseases complicating pregnancy, and FE(NO) may be helpful for monitoring asthma in pregnancy. However, some physiological alterations of FE(NO) may be expected during healthy pregnancy due to vascular nitric oxide production. Until now no study assessed the level of FE(NO) in asthmatic pregnant patients.
We aimed to assess the possible use and reproducibility of FE(NO) measurements in pregnant asthmatic women. We compared FE(NO) concentrations between four groups of subjects: healthy nonpregnant and pregnant females and asthmatic nonpregnant and pregnant patients. We also investigated the relationship between FE(NO) values and the level of asthma control in pregnant asthmatic patients.
A total of 102 female subjects (35 healthy nonpregnant and 27 healthy pregnant females; 20 nonpregnant and 20 pregnant asthmatic women) were included in this cross-sectional study. Two FE(NO) measurements were performed in each subject using an electrochemical sensor based device (NIOX MINO, Aerocrine, Solna, Sweden). Data are given as median with range.
The repeatability of FE(NO) measurement was similar in pregnant and nonpregnant subjects. FE(NO) levels did not differ significantly between healthy pregnant versus nonpregnant subjects (16.0 [8, 31] vs. 16.0 [9, 35] ppb). FE(NO) levels were significantly increased in asthmatic women compared to healthy females (nonpregnant asthmatics: 38 [9, 54] ppb, p < 0.001 vs. healthy nonpregnant; pregnant asthmatic patients: 28 [10, 56] ppb; p < 0.05 vs. healthy pregnant).
FE(NO) level is not influenced by healthy pregnancy. In pregnant asthmatic patients FE(NO) level is elevated compared to healthy pregnant subjects and correlates with the level of asthma control. Further studies are required to assess the use of FE(NO) measurement to monitor asthma in this patient group.
测定呼出一氧化氮（FE(NO)）分数有助于监测哮喘患者的气道炎症。哮喘是妊娠最常见的并发症之一，FE(NO)可能有助于监测妊娠期哮喘。然而，由于血管内一氧化氮的产生，在健康妊娠期间FE(NO)可能会发生一些生理变化。迄今为止，尚无研究评估哮喘妊娠患者的FE(NO)水平。
我们旨在评估FE(NO)测量在妊娠哮喘女性中的可能用途和可重复性。我们比较了四组受试者的FE(NO)浓度：健康未孕和妊娠女性以及哮喘未孕和妊娠患者。我们还研究了妊娠哮喘患者FE(NO)值与哮喘控制水平之间的关系。
本横断面研究共纳入102名女性受试者（35名健康未孕女性和27名健康妊娠女性；20名未孕哮喘女性和20名妊娠哮喘女性）。使用基于电化学传感器的设备（NIOX MINO，Aerocrine，瑞典索尔纳）对每位受试者进行两次FE(NO)测量。数据以中位数及范围表示。
FE(NO)测量的可重复性在妊娠和未孕受试者中相似。健康妊娠与未孕受试者之间的FE(NO)水平无显著差异（分别为16.0 [8, 31] ppb和16.0 [9, 35] ppb）。与健康女性相比，哮喘女性的FE(NO)水平显著升高（未孕哮喘患者：38 [9, 54] ppb，与健康未孕女性相比p < 0.001；妊娠哮喘患者：28 [10, 56] ppb；与健康妊娠女性相比p < 0.05）。
FE(NO)水平不受健康妊娠的影响。妊娠哮喘患者的FE(NO)水平高于健康妊娠受试者，并与哮喘控制水平相关。需要进一步研究以评估FE(NO)测量在该患者群体中监测哮喘的用途。
