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妊娠期哮喘：病理生理学、诊断、全程管理和药物安全性。

Asthma in Pregnancy: Pathophysiology, Diagnosis, Whole-Course Management, and Medication Safety.

机构信息

Department of Respiration and Critical Care Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310000, China.

出版信息

Can Respir J. 2020 Feb 22;2020:9046842. doi: 10.1155/2020/9046842. eCollection 2020.

DOI:10.1155/2020/9046842
PMID:32184907
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7060439/
Abstract

Asthma in pregnancy is a health issue of great concern. Physiological changes and drug compliance during pregnancy can affect asthma control in varying degrees, and the control level of asthma and the side effects of asthma medications are closely related to the adverse perinatal outcomes of mother and fetus. This article provides an update on the available literature regarding the alleviating or aggravating mechanism of asthma in pregnancy, diagnosis, disease assessment, and systematic management, to provide a new guidance for physician, obstetric joint doctor, and health care practitioner.

摘要

孕期哮喘是一个备受关注的健康问题。孕期的生理变化和药物依从性会在不同程度上影响哮喘的控制，而哮喘的控制水平和哮喘药物的副作用与母婴围产期不良结局密切相关。本文就目前有关孕期哮喘的发病机制、诊断、病情评估及系统管理的研究进展进行综述，以期为临床医生、产科医生及妇幼保健工作者提供新的指导。

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本文引用的文献

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Medications that Cause Fetal Anomalies and Possible Prevention Strategies.导致胎儿畸形的药物及可能的预防策略。
Clin Perinatol. 2019 Jun;46(2):203-213. doi: 10.1016/j.clp.2019.02.003. Epub 2019 Mar 28.
2
Parental asthma and risk of autism spectrum disorder in offspring: A population and family-based case-control study.父母哮喘与后代自闭症谱系障碍风险的相关性：基于人群和家庭的病例对照研究。
Clin Exp Allergy. 2019 Jun;49(6):883-891. doi: 10.1111/cea.13353. Epub 2019 Feb 27.
3
The course of asthma during pregnancy in a recent, multicase-control study on respiratory health.在最近一项关于呼吸健康的多病例对照研究中，哮喘在孕期的发展过程。
Allergy Asthma Clin Immunol. 2018 Apr 17;14:16. doi: 10.1186/s13223-018-0242-0. eCollection 2018.
4
Benralizumab (Fasenra) for Severe Eosinophilic Asthma.贝那利珠单抗（法舒克）用于治疗重度嗜酸性粒细胞性哮喘。
JAMA. 2018 Apr 10;319(14):1501-1502. doi: 10.1001/jama.2018.3609.
5
Asthma knowledge, care, and outcome during pregnancy: The QAKCOP study.哮喘知识、护理和妊娠结局：QAKCOP 研究。
Chron Respir Dis. 2019 Jan-Dec;16:1479972318767719. doi: 10.1177/1479972318767719. Epub 2018 Apr 5.
6
Managing Asthma in Pregnancy (MAP) trial: FENO levels and childhood asthma.妊娠合并哮喘管理（MAP）试验：FeNO 水平与儿童哮喘。
J Allergy Clin Immunol. 2018 Dec;142(6):1765-1772.e4. doi: 10.1016/j.jaci.2018.02.039. Epub 2018 Mar 8.
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