Süslü Nilda, Yilmaz Taner, Gürsel Bülent
Department of Otolaryngology-Head and Neck Surgery, Hacettepe University Faculty of Medicine, Sihhiye, Ankara, Turkey.
Acta Otolaryngol. 2009 Nov;129(11):1160-5. doi: 10.3109/00016480802631966.
Because of the lack of association between a positive test and response to corticosteroid treatment, at present, detection of anti-HSP 70 antibody, tumor necrosis factor (TNF)-alpha, erythrocyte sedimentation rate (ESR), or antinuclear antibody (ANA), does not offer clinically useful information in the treatment of Meniere's disease (MD).
The study was designed to investigate the performance of various laboratory tests, including anti-HSP 70, TNF-alpha, ESR, ANA, and anti-phospholipid antibodies, in the diagnosis and treatment response of patients with MD.
Thirty patients who presented with MD and 30 healthy people were selected as study and control groups, respectively. The laboratory panel included the following tests: anti-HSP 70 antibody immunoassay, TNF-alpha, ESR, ANA, and anti-phospholipid antibodies. The study group was given corticosteroid therapy and separated into two groups: the corticosteroid responders and the corticosteroid non-responders. In the follow-up, repeat audiograms were evaluated to determine the response to treatment.
TNF-alpha was found at significantly lower titers in the study group when compared with the control group (p<0.05). Anti-HSP 70 was not found in high titers in the study group. ANA positivity in patients with MD was not statistically different from the control group. There was no significant difference in the treatment response for any of the parameters tested.
由于阳性检测结果与皮质类固醇治疗反应之间缺乏关联，目前，检测抗热休克蛋白70（HSP 70）抗体、肿瘤坏死因子（TNF）-α、红细胞沉降率（ESR）或抗核抗体（ANA），在梅尼埃病（MD）的治疗中未提供临床有用信息。
本研究旨在调查各种实验室检查，包括抗HSP 70、TNF-α、ESR、ANA和抗磷脂抗体，在MD患者诊断和治疗反应中的表现。
分别选取30例MD患者和30例健康人作为研究组和对照组。实验室检查项目包括：抗HSP 70抗体免疫测定、TNF-α、ESR、ANA和抗磷脂抗体。研究组接受皮质类固醇治疗，并分为两组：皮质类固醇治疗反应者和皮质类固醇治疗无反应者。在随访中，评估重复听力图以确定治疗反应。
与对照组相比，研究组中TNF-α滴度显著较低（p<0.05）。研究组未发现高滴度的抗HSP 70。MD患者的ANA阳性率与对照组无统计学差异。所检测的任何参数在治疗反应方面均无显著差异。
