Bhosle Sushma Madhukar, Ahire Vidhula R, Henry Monica S, Thakur Vikas S, Huilgol Nagraj G, Mishra Kaushala Prasad
Bhabha Atomic Research Centre, Radiation Biology and Health Sciences Division, Trombay, Mumbai, India.
Cancer Invest. 2010 Mar;28(3):323-30. doi: 10.3109/07357900902849616.
This study evaluates the potential of ellagic acid (EA) as an enhancer of radiation-induced apoptosis in cancer cells. HeLa cells treated with EA and gamma radiation showed increased superoxide generation, upregulated p53 protein expression, and decreased antioxidant enzymes. We also found that EA and radiation enhance capase-3 activity via oxidative stress, increased intracellular calcium levels, and phospholipase C and cause a drop in mitochondrial potential. These results might provide a basis for prominent reduction of cancer cell using EA as an adjunct to radiotherapy and an opportunity to lower the toxic radiation doses to improve the quality of life.
本研究评估了鞣花酸（EA）作为癌细胞辐射诱导凋亡增强剂的潜力。用EA和γ辐射处理的HeLa细胞显示超氧化物生成增加、p53蛋白表达上调以及抗氧化酶减少。我们还发现，EA和辐射通过氧化应激、细胞内钙水平升高、磷脂酶C增强半胱天冬酶-3活性，并导致线粒体电位下降。这些结果可能为使用EA作为放射治疗辅助手段显著减少癌细胞提供依据，并为降低毒性辐射剂量以改善生活质量提供机会。
