Laboratory of Biochemistry, Department of Biotechnology, University of Malakand, Chakdara, Lower Dir, Khyber Pakhtunkhwa, Pakistan.
Mol Cell Biochem. 2018 Nov;448(1-2):27-41. doi: 10.1007/s11010-018-3310-3. Epub 2018 Jan 31.
Oxidative stress is a biological condition produced by a variety of factors, causing several chronic diseases. Oxidative stress was, therefore, treated with natural antioxidants, such as ellagic acid (EA). EA has a major role in protecting against different diseases associated with oxidative stress. This review critically discussed the antioxidant role of EA in biological systems. The in vitro and in vivo studies have confirmed the protective role of EA in suppressing oxidative stress. The review also discussed the mechanism of EA in suppressing of oxidative stress, which showed that EA activates specific endogenous antioxidant enzymes and suppresses specific genes responsible for inflammation, diseases, or disturbance of biochemical systems. The amount of EA used and duration, which plays a significant role in the treatment of oxidative stress has been discussed. In conclusion, EA is a strong natural antioxidant, which possesses the suppressing power of oxidative stress in biological systems.
氧化应激是由多种因素引起的一种生物状态，会导致多种慢性疾病。因此，氧化应激可以用天然抗氧化剂如鞣花酸（EA）来治疗。EA 在预防与氧化应激相关的各种疾病方面起着重要作用。本综述批判性地讨论了 EA 在生物系统中的抗氧化作用。体外和体内研究证实了 EA 在抑制氧化应激方面的保护作用。该综述还讨论了 EA 抑制氧化应激的机制，表明 EA 激活特定的内源性抗氧化酶，并抑制特定的基因，这些基因负责炎症、疾病或生化系统的紊乱。EA 的用量和作用时间在氧化应激的治疗中起着重要作用。总之，EA 是一种强大的天然抗氧化剂，具有在生物系统中抑制氧化应激的能力。
