Department of Microbiology, Hospital Clínico Lozano Blesa, Zaragoza, Spain.
Clin Microbiol Infect. 2010 Jul;16(7):1005-7. doi: 10.1111/j.1469-0691.2009.02958.x. Epub 2009 Oct 28.
A qnrS2 gene was identified in an Aeromonas caviae isolate (MICs of ciprofloxacin, norfloxacin and ofloxacin >32 mg/L) from a stool sample collected from a patient with gastroenteritis. The analysis of the gyrA and parC genes revealed amino acid substitutions Ser83-Ile and Ser80-Thr, respectively. In addition, five out of 41 nalidixic acid-resistant Aeromonas isolates studied (26 identified as Aeromonas veronii bv sobria and 15 identified as A. caviae) showed ciprofloxacin resistance. The identification of plasmid-mediated qnr genes outside of the Enterobacteriaceae underlines a possible diffusion of these resistance determinants among Gram-negative rods. This emphasizes the importance of monitoring the emergence of these determinants as well as their dissemination among the Aeromonadaceae.
从肠胃炎患者粪便样本中分离出的豚鼠气单胞菌（MICs 对环丙沙星、诺氟沙星和氧氟沙星＞32mg/L）中鉴定出 qnrS2 基因。gyrA 和 parC 基因分析显示分别存在丝氨酸 83 异亮氨酸和丝氨酸 80 苏氨酸取代。此外，在所研究的 41 株萘啶酸耐药气单胞菌分离株中，有 5 株（26 株鉴定为温和气单胞菌亚种，15 株鉴定为豚鼠气单胞菌）表现出对环丙沙星的耐药性。肠杆菌科以外的质粒介导 qnr 基因的鉴定强调了这些耐药决定因素在革兰氏阴性杆菌中的可能传播。这强调了监测这些决定因素的出现以及它们在气单胞菌科中的传播的重要性。
