Center for Cancer Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Prostate. 2010 Mar 1;70(4):425-32. doi: 10.1002/pros.21076.
Several genome-wide association studies (GWAS) in populations of European descent have identified more than a dozen common genetic variants that are associated with prostate cancer risk.
To determine whether these variants are also associated with prostate cancer risk in the Chinese population, we evaluated 17 prostate cancer susceptibility loci in a population-based case-control study from Shanghai, including 288 prostate cancer cases and 155 population controls.
After adjustment for age, two of the 17 loci were significantly associated with prostate cancer risk, while the other 15 loci were suggestively associated with prostate cancer risk in this population. The strongest associations were found for chromosome 8q24 Region 2 (rs1016343: OR = 2.07, 95% CI: 1.35-3.20, P = 9.4 x 10(-4)) and 8q24 Region 1 (rs10090154: OR = 2.07, 95% CI: 1.31-3.28, P = 0.002); additional single nucleotide polymorphisms (SNPs) assessed in these two 8q24 regions were also significant (OR(Region2) = 1.92-2.05, P = 9.4 x 10(-4) to 0.003, and OR(Region1) = 1.77-1.81, P = 0.01 for all SNPs).
Our study shows that multiple prostate cancer risk loci identified in European populations by GWAS are also associated with prostate cancer risk in Chinese men, a low-risk population with mostly clinically relevant cancers. Larger studies in Chinese and Asian populations are needed to confirm these findings and the role of these risk loci in prostate cancer etiology in Asian men.
在欧洲血统的人群中进行的几项全基因组关联研究（GWAS）已经确定了十多个与前列腺癌风险相关的常见遗传变异。
为了确定这些变异是否也与中国人群中的前列腺癌风险相关，我们在上海进行了一项基于人群的病例对照研究，评估了 17 个前列腺癌易感性基因座，包括 288 例前列腺癌病例和 155 例人群对照。
在调整年龄后，这 17 个基因座中的两个与前列腺癌风险显著相关，而其他 15 个基因座在该人群中提示与前列腺癌风险相关。最强的关联位于 8 号染色体 24 区 2（rs1016343：OR = 2.07，95%CI：1.35-3.20，P = 9.4 x 10(-4)）和 8 号染色体 24 区 1（rs10090154：OR = 2.07，95%CI：1.31-3.28，P = 0.002）；在这两个 8q24 区域评估的其他单核苷酸多态性（SNP）也很显著（OR（Region2）= 1.92-2.05，P = 9.4 x 10(-4)至 0.003，OR（Region1）= 1.77-1.81，P = 0.01 对于所有 SNP）。
我们的研究表明，通过 GWAS 在欧洲人群中确定的多个前列腺癌风险基因座也与中国男性的前列腺癌风险相关，中国男性是一个低风险人群，其癌症大多与临床相关。需要在中国和亚洲人群中进行更大规模的研究，以证实这些发现以及这些风险基因座在亚洲男性前列腺癌发病机制中的作用。
