Boston.
J Exp Med. 1907 Jul 17;9(4):325-51. doi: 10.1084/jem.9.4.325.
A histological study of six cases of myeloma shows a striking similarity of cell structure with differences of minor degree. The common characteristics of the cells are a finely granular, slightly basophilic cytoplasm, an eccentrically placed nucleus, a nucleolus, centrosomes, a nuclear membrane and a tendency to mural arrangement of the chromatin. With these characteristics there is a greater resemblance of the tumor cells to bone marrow plasma cells than to myelocytes. In most of the cases reported by other observers the cells show these characteristics and these tumors form a group within which the cells of individual cases show no greater variation than occurs in other tumor groups.
对 6 例骨髓瘤的组织学研究表明，细胞结构具有显著的相似性，仅有微小的差异。细胞的共同特征是：细胞质呈细颗粒状，略带嗜碱性，偏心核，核仁，中心体，核膜和染色质壁排列的趋势。这些特征使肿瘤细胞与骨髓浆细胞的相似性大于与成髓细胞。在其他观察者报道的大多数病例中，细胞表现出这些特征，这些肿瘤形成一个群体，其中单个病例的细胞变化程度与其他肿瘤群体没有更大的差异。
