疟色素（所谓的黑色素）：其性质及其产生方式。
MALARIAL PIGMENT (SO-CALLED MELANIN): ITS NATURE AND MODE OF PRODUCTION.
机构信息
Pathological Laboratory of the University of Wisconsin, Madison, Wisconsin.
出版信息
J Exp Med. 1911 Feb 1;13(2):290-9. doi: 10.1084/jem.13.2.290.
Abstract
- Two important methods for the study of malarial pigment are described. (a) A method for obtaining a solution of malarial pigment from fixed tissues without the removal of a trace of hemoglobin from the red blood corpuscles. (b) A method for obtaining an iron reaction in malarial pigment. 2. By comparing the bleach reactions and solubility of melanins and malarial pigment, the dissimilarity of the two classes of pigments has been demonstrated. 3. The spectroscopic examination of a solution of malarial pigment proves conclusively that the pigment is hematin. 4. It is suggested that the action of a proteolytic enzyme of the malarial parasite upon the hemoglobin of the red blood corpuscle is the most probable mode of elaboration of malarial pigment. 5. The difficulty with which the human organism disposes of malarial pigment indicates that the production of hematin cannot be considered as a normal intermediate process in the formation of bile pigments from hemoglobin.
摘要
描述了两种研究疟色素的重要方法。(a)一种从固定组织中获得疟色素溶液的方法，而不会从红细胞中去除任何痕量的血红蛋白。(b)一种获得疟色素中铁反应的方法。
通过比较黑色素和疟色素的漂白反应和溶解度，证明了这两类色素的不同。
疟色素溶液的光谱检查确凿地证明了该色素是血晶素。
有人认为疟原虫的一种蛋白水解酶对红细胞血红蛋白的作用是疟色素产生的最可能模式。
人体清除疟色素的困难表明，从血红蛋白生成胆色素的过程中，生成血晶素不能被认为是正常的中间过程。
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