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疟色素（所谓的黑色素）：其性质及其产生方式。

MALARIAL PIGMENT (SO-CALLED MELANIN): ITS NATURE AND MODE OF PRODUCTION.

机构信息

Pathological Laboratory of the University of Wisconsin, Madison, Wisconsin.

出版信息

J Exp Med. 1911 Feb 1;13(2):290-9. doi: 10.1084/jem.13.2.290.

DOI:10.1084/jem.13.2.290
PMID:19867409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2124860/
Abstract
  1. Two important methods for the study of malarial pigment are described. (a) A method for obtaining a solution of malarial pigment from fixed tissues without the removal of a trace of hemoglobin from the red blood corpuscles. (b) A method for obtaining an iron reaction in malarial pigment. 2. By comparing the bleach reactions and solubility of melanins and malarial pigment, the dissimilarity of the two classes of pigments has been demonstrated. 3. The spectroscopic examination of a solution of malarial pigment proves conclusively that the pigment is hematin. 4. It is suggested that the action of a proteolytic enzyme of the malarial parasite upon the hemoglobin of the red blood corpuscle is the most probable mode of elaboration of malarial pigment. 5. The difficulty with which the human organism disposes of malarial pigment indicates that the production of hematin cannot be considered as a normal intermediate process in the formation of bile pigments from hemoglobin.
摘要

  1. 描述了两种研究疟色素的重要方法。(a)一种从固定组织中获得疟色素溶液的方法，而不会从红细胞中去除任何痕量的血红蛋白。(b)一种获得疟色素中铁反应的方法。

  2. 通过比较黑色素和疟色素的漂白反应和溶解度，证明了这两类色素的不同。

  3. 疟色素溶液的光谱检查确凿地证明了该色素是血晶素。

  4. 有人认为疟原虫的一种蛋白水解酶对红细胞血红蛋白的作用是疟色素产生的最可能模式。

  5. 人体清除疟色素的困难表明，从血红蛋白生成胆色素的过程中，生成血晶素不能被认为是正常的中间过程。

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1
MALARIAL PIGMENT (SO-CALLED MELANIN): ITS NATURE AND MODE OF PRODUCTION.疟色素（所谓的黑色素）：其性质及其产生方式。
J Exp Med. 1911 Feb 1;13(2):290-9. doi: 10.1084/jem.13.2.290.
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MALARIAL PIGMENT (HEMATIN) AS A FACTOR IN THE PRODUCTION OF THE MALARIAL PAROXYSM.疟色素（血红素）在疟疾发作中的作用。
J Exp Med. 1912 Jun 1;15(6):579-97. doi: 10.1084/jem.15.6.579.
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A STAGE IN THE MIGRATION OF THE ADULT TERTIAN MALARIAL PARASITE. EVIDENCE OF THE EXTRACELLULAR RELATION OF THE PARASITE TO THE RED CORPUSCLE.按蚊生活史各期的观察。疟原虫与红细胞的关系的研究。
J Exp Med. 1914 May 1;19(5):450-8. doi: 10.1084/jem.19.5.450.
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J Exp Med. 1932 Sep 30;56(4):551-73. doi: 10.1084/jem.56.4.551.
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Purification and some properties of malarial pigment.疟色素的纯化及其某些性质
Ann Trop Med Parasitol. 1975 Sep;69(3):283-7. doi: 10.1080/00034983.1975.11687012.
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SEGMENTING TERTIAN MALARIAL PARASITES ON RED CORPUSCLES SHOWING LITTLE OR NO LOSS OF HEMOGLOBIN SUBSTANCE. EVIDENCE OF MIGRATION.在几乎没有丢失血红蛋白物质的红细胞上对三日疟原虫进行分割。有迁移的证据。
J Exp Med. 1920 Jul 31;32(2):139-42. doi: 10.1084/jem.32.2.139.
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Impairment of macrophage functions after ingestion of Plasmodium falciparum-infected erythrocytes or isolated malarial pigment.摄入恶性疟原虫感染的红细胞或分离出的疟色素后巨噬细胞功能受损。
J Exp Med. 1992 Oct 1;176(4):1033-41. doi: 10.1084/jem.176.4.1033.
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FREE MALARIAL PARASITES AND THE EFFECT OF THE MIGRATION OF THE PARASITES OF TERTIAN MALARIAL INFECTIONS.疟原虫血症和三日疟原虫寄生虫迁移对疟疾寄生虫的影响。
J Exp Med. 1914 Jun 1;19(6):523-35. doi: 10.1084/jem.19.6.523.
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AESTIVO-AUTUMNAL MALARIA. THE EXTRACELLULAR RELATION OF THE CRESCENTIC BODIES TO THE RED CORPUSCLE AND THEIR METHOD OF SECURING ATTACHMENT.间日疟原虫。新月形小体与红细胞的细胞外关系及其附着方法。
J Exp Med. 1918 Jun 1;27(6):739-48. doi: 10.1084/jem.27.6.739.
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ADULT TERTIAN MALARIAL PARASITES ATTACHED TO PERIPHERAL CORPUSCULAR MOUNDS. THE EXTRACELLULAR RELATION OF THE PARASITES TO THE RED CORPUSCLES.成人三日疟原虫附着在周边颗粒状丘上。寄生虫与红细胞的细胞外关系。
J Exp Med. 1915 Jun 1;21(6):584-92. doi: 10.1084/jem.21.6.584.

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