The Saranac Laboratory for the Study of Tuberculosis, Saranac Lake.
J Exp Med. 1914 Jul 1;20(1):81-91. doi: 10.1084/jem.20.1.81.
The determination of the percentage of CO(2) in the alveolar air, by the method of Haldane and Priestley, is sufficiently accurate for clinical purposes when the individual is at rest. It is evident, however, that an error may arise in the determination of the percentage of CO(2) in the alveolar air, due to the time during the forced expiration, short of the extreme limit, at which the sample may be unconsciously taken. This error can only be overcome by taking several samples. In individuals at rest having a tidal air below 425 cubic centimeters, the method of Douglas and Haldane for the calculation of the dead space gives approximately accurate results; with a tidal air above 425 cubic centimeters the results obtained may be wholly inaccurate. In patients with marked pulmonary tuberculosis so slight an effort as that involved in collecting the expired air tends to lower the percentage of CO(2) in the alveolar air. In collecting the expired air by the rubber bag method, it is absolutely essential that the bag be washed out with ordinary atmospheric air after every observation.
通过 Haldane 和 Priestley 方法测定肺泡空气中的二氧化碳百分比，在个体处于休息状态时，对于临床目的来说已经足够准确。然而，由于在强制呼气期间的时间，可能会导致肺泡空气中的二氧化碳百分比的测定出现误差，以至于样本可能会在无意识的情况下被取出。只有通过多次采样才能克服这种误差。在潮气量低于 425 立方厘米的休息个体中，Douglas 和 Haldane 计算死腔的方法可以得到大致准确的结果；在潮气量高于 425 立方厘米时，所得到的结果可能完全不准确。在有明显肺结核的患者中，收集呼气所涉及的轻微努力往往会降低肺泡空气中的二氧化碳百分比。在使用橡胶袋法收集呼气时，每次观察后都必须用普通大气空气彻底冲洗袋子。
