Kitasato Institute for Infectious Diseases, Tokyo, Japan.
J Exp Med. 1916 Aug 1;24(2):187-206. doi: 10.1084/jem.24.2.187.
Cyanocuprol is markedly effective in tuberculosis, and we believe that it will play an important part in clinical medicine. It may be used more generally than tuberculin. The amount of the dose is closely related to the reaction and the final results. It should be determined for each patient after a careful examination of his symptoms. The maximum dose of 8.5 cc. should in no case be exceeded. The shortest interval between injections should be 2 weeks. If the drug is given after a shorter interval, no improvement is observed and the effects are sometimes dangerous. In order to obtain the best results the patient should be placed under conditions of complete physical and mental rest after the injection; this applies even to light cases. Care should also be taken to secure rest for the lesion. During the period of the treatment irritants to the lesion, such as potassium iodide or tuberculin, should be avoided; apricot juice, guaiacol and its derivatives, and iodol are contraindicated. No marked idiosyncrasy has been noted and no accumulative effects have been observed.
氰酸铜在治疗肺结核方面效果显著，我们相信它将在临床医学中发挥重要作用。它的使用可能比结核菌素更广泛。剂量的多少与反应和最终结果密切相关。应在仔细检查患者症状后为每位患者确定剂量。在任何情况下，都不应超过 8.5 毫升的最大剂量。两次注射之间的最短间隔应为 2 周。如果在更短的间隔内给予药物，则不会观察到改善，并且效果有时是危险的。为了获得最佳效果，患者在注射后应在身体和精神完全休息的条件下进行；即使是轻症患者也应如此。还应注意确保病变部位的休息。在治疗期间，应避免使用病变部位的刺激性药物，如碘化钾或结核菌素；杏仁汁、愈创木酚及其衍生物和碘醇都禁用。未观察到明显的过敏反应，也未观察到累积效应。
