吸入溶血性链球菌、弗氏杆菌和肺炎球菌后小鼠实验性肺炎的病理学。
PATHOLOGY OF THE EXPERIMENTAL PNEUMONIAS IN MICE FOLLOWING INHALATION OF STREPTOCOCCUS HAEMOLYTICUS, OF FRIEDLANDER'S BACILLUS, AND OF PNEUMOCOCCUS.
机构信息
Hospital of The Rockefeller Institute for Medical Research.
出版信息
J Exp Med. 1925 Apr 30;41(5):631-8. doi: 10.1084/jem.41.5.631.
Abstract
- Pulmonary consolidation may be produced in normal mice by the inhalation of Friedländer's bacillus or Streptococcus haemolylicus. 2. The initial lesion is in both instances interstitial in character and the spread is by way of the interstitial tissue, though the ultimate consolidation may come to resemble in the gross a lobar pneumonia. 3. The lesions grossly and microscopically may be distinguished from the lobar consolidation associated with pneumococcus infection of the lung. 4. Friedländer's bacillus and Streptococcus haemolyticus give rise to pneumonia in mice previously normal, whereas the pneumococcus produces pulmonary lesions only under special circumstances, as when the animals are alcoholized after partial immunization.
摘要
正常小鼠吸入弗氏杆菌或溶血性链球菌可引起肺实变。
在这两种情况下，初始病变均为间质特征，传播途径为间质组织，但最终的实变可能在大体上类似于大叶性肺炎。
大体和显微镜下的病变可与与肺炎球菌感染相关的大叶性肺炎实变区分开来。
弗氏杆菌和溶血性链球菌可引起原本正常的小鼠发生肺炎，而肺炎球菌仅在特殊情况下，如部分免疫后动物被酒精化时，才会引起肺部病变。
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J Exp Med. 1925 Apr 30;41(5):623-30. doi: 10.1084/jem.41.5.623.
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