牛源致病性 B 型大肠杆菌的研究：II. 突变及其免疫学意义。
STUDIES ON PATHOGENIC B. COLI FROM BOVINE SOURCES : II. MUTATIONS AND THEIR IMMUNOLOGICAL SIGNIFICANCE.
机构信息
Department of Animal Pathology of The Rockefeller Institute for Medical Research, Princeton, N. J.
出版信息
J Exp Med. 1927 Jun 30;46(1):133-40. doi: 10.1084/jem.46.1.133.
Abstract
On agar plates certain strains of B. coli from the ileum of calves suffering from diarrhea or scours promptly mutate and give rise to forms which have lost capsular substance, whose virulence has been greatly reduced, and which have gained very greatly in agglutinability and in being taken up by leucocytes. The original characters are not regained in cultures kept in the cold after development, nor in rapid transfers in bouillon, nor in passages through the peritoneal cavity of guinea pigs. Filtrates of 48 hour bouillon cultures contain as much toxin in the (b) as in the (a) form indicating no loss in this function.
摘要
在琼脂平板上，来自患有腹泻或痢疾的犊牛回肠的某些 B. coli 菌株会迅速突变，并产生丧失荚膜物质的形式，其毒力大大降低，并且凝集能力和被白细胞摄取的能力大大增强。在培养物在低温下保存后、在肉汤中快速转移后或在通过豚鼠腹腔传递后，不会恢复原始特征。48 小时肉汤培养物的滤液在 (b) 形式中含有与 (a) 形式相同的毒素，表明在此功能中没有损失。
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